Simpson E, Rao L G, Evans R M, Wilkie W, Rodger J C, Lakhani A
Ann Clin Biochem. 1980 Jan;17(1):10-4. doi: 10.1177/000456328001700102.
A patient was admitted to a district general hospital within an hour of ingesting a fatal dose of sodium fluoride. The results of laboratory investigations, together with some in vitro findings, support the hypothesis that the hypocalcaemia of fluoride poisoning is the result of fluorapatite formation and not calcium fluoride precipitation, and that its persistence reflects the severity of the calcium deficit and not an inhibitoin of normal homeostatic mechanisms. It is suggested that the role of renal clearance of fluoride may be more important than had been realised hitherto.
一名患者在摄入致命剂量的氟化钠后一小时内被送往一家地区综合医院。实验室检查结果以及一些体外研究结果支持以下假设：氟中毒导致的低钙血症是氟磷灰石形成的结果，而非氟化钙沉淀所致，其持续存在反映的是钙缺乏的严重程度，而非正常稳态机制受到抑制。有人提出，肾脏对氟的清除作用可能比迄今所认识到的更为重要。
