患有和未患有慢性肝病的受试者口服和静脉注射胆酸后的血浆清除率。
Plasma clearance of oral and intravenous cholic acid in subjects with and without chronic liver disease.
作者信息
Gilmore I T, Thompson R P
出版信息
Gut. 1980 Feb;21(2):123-7. doi: 10.1136/gut.21.2.123.
Abstract
The apparent plasms clearances of tracer amounts of radiolabelled cholic acid given orally or intravenously were compared in 14 control subjects and 20 patients with chronic liver disease. The clearance after oral administration was the more sensitive in detecting chronic liver disease and correlated better with the fasting levels of endogenous serum bile acid. This agrees with the predicted effects on clearance of hepatocellular damage and portal-systemic shunting of blood after the two routes of administration. The estimated hepatic extraction ratio, calculated from the ratio of the oral and intravenous clearances, was 0.77+/-0.02 (mean+/-SEM) in control subjects, 0.64+/-0.03 in patients with anicteric chronic liver disease, and 0.46+/-0.05 in those with icteric chronic liver disease.
摘要
对14名对照受试者和20名慢性肝病患者口服或静脉注射微量放射性标记胆酸后的表观血浆清除率进行了比较。口服给药后的清除率在检测慢性肝病方面更敏感，并且与内源性血清胆汁酸的空腹水平相关性更好。这与两种给药途径后对肝细胞损伤清除率和门体分流的预期影响一致。根据口服和静脉清除率的比值计算出的估计肝提取率，在对照受试者中为0.77±0.02（平均值±标准误），在无黄疸慢性肝病患者中为0.64±0.03，在黄疸慢性肝病患者中为0.46±0.05。
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