肝病中的胆汁酸清除率
Bile acid clearance in liver disease.
作者信息
Luey L K, Heaton K W
出版信息
Gut. 1979 Dec;20(12):1083-7. doi: 10.1136/gut.20.12.1083.
Abstract
The disappearance of intravenously administered cholylglycine-14C was studied in the fasting and postprandial states in seven subjects with healthy livers and 10 patients with liver disease. In neither group was there any significant difference in the pattern of 14C disappearance. In another 10 patients with liver disease there was no significant change when a loading dose of cholylglycine was given orally two hours beforehand. Clearance of bile acids seems to be unimpaired in all except severe liver disease. The apparent deterioration in endogenous bile acid removal after meals may be due simply to the increased amount of bile acids which are in circulation and available for portosystemic shunting.
摘要
对7名肝脏健康的受试者和10名肝病患者在空腹和餐后状态下静脉注射甘氨胆酰 - 14C后的消失情况进行了研究。两组中14C消失模式均无显著差异。在另外10名肝病患者中，提前两小时口服甘氨胆酰负荷剂量后，也没有显著变化。除严重肝病外，胆汁酸清除似乎未受损害。餐后内源性胆汁酸清除的明显恶化可能仅仅是由于循环中胆汁酸量增加，可供门体分流。
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本文引用的文献
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Increased incidence of cholelithiasis in Laënnec's cirrhosis. A postmortem evaluation of pathogenesis.Laënnec肝硬化患者胆石症发病率增加。发病机制的尸检评估。
Gastroenterology. 1972 Jul;63(1):112-21.
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