Poulter L W
Clin Exp Immunol. 1980 Apr;40(1):25-35.
The effect of initiating leishmanial infection in guinea-pigs with organisms contained within macrophages has been examined. Infection of animals in this way resulted in the development of metastatic disease with inocula 2 logs lower than required when free parasites were injected. The macrophage localization was found to protect the parasite from innate resistance, and, at certain times, from mechanisms of acquired immunity. Despite this, initiation of infection with parasites secluded in macrophages did result in the development of specific cell-mediated and humoral immunity. The results indicate that protection of the parasite by the macrophage contributes to the development of metastatic disease. Furthermore, it was revealed that metastatic disease can devlop in the face of acquired mechanisms of resistance. The possibility that non-healing diffuse leishmaniasis is the cause rather than the result of the suppressed immunological reactivity associated with this disease is discussed.
研究了用巨噬细胞内所含生物体引发豚鼠利什曼原虫感染的效果。以这种方式感染动物会导致转移性疾病的发展，接种量比注射游离寄生虫时所需的低2个对数。发现巨噬细胞定位可保护寄生虫免受先天抵抗力影响，并且在某些时候免受获得性免疫机制影响。尽管如此，用隔离在巨噬细胞内的寄生虫引发感染确实会导致特异性细胞介导免疫和体液免疫的发展。结果表明，巨噬细胞对寄生虫的保护有助于转移性疾病的发展。此外，还发现转移性疾病可在存在获得性抵抗机制的情况下发生。讨论了非愈合性弥漫性利什曼病是与该疾病相关的免疫反应受抑制的原因而非结果的可能性。
