Poulter L W
Clin Exp Immunol. 1979 Apr;36(1):30-7.
Quantitative methods for enumerating viable L. enriettii in tissues have been used to determine the course of cutaneous leishmaniasis in guinea-pigs. The development and kinetics of acquired resistance have been evaluated in self-healing and chronic metastatic forms of the disease. It is revealed that 3 weeks after a primary local infection, a standard challenge infection is totally eliminated within 7 days. This resistance is as strong in animals with a current infection as it is in those that have fully recovered from such an infection. Animals developing metastatic disease also develop resistance to the standard challenge. This is initially as strong as in animals with only localized disease, but wanes with the progression of the infection. Although the quality of resistance becomes poorer in animals with metastatic infection, it is not lost completely. The relationship between acquired resistance and the resolution of the primary infection is discussed.
已采用定量方法对组织中活的恩氏利什曼原虫进行计数，以确定豚鼠皮肤利什曼病的病程。在该疾病的自愈型和慢性转移型中评估了获得性抗性的发展和动力学。结果显示，在原发性局部感染3周后，标准激发感染在7天内被完全清除。这种抗性在当前感染的动物中与已从这种感染中完全康复的动物中一样强。发生转移性疾病的动物也会对标准激发产生抗性。这种抗性最初与仅患有局部疾病的动物中的抗性一样强，但会随着感染的进展而减弱。尽管转移性感染动物的抗性质量变差，但并未完全丧失。文中讨论了获得性抗性与原发性感染消退之间的关系。
