Mau G
Eur J Pediatr. 1980 May;133(3):233-7. doi: 10.1007/BF00496082.
On the basis of prospectively collected data from 7,525 pregnancies it was examined whether moderate but daily alcohol consumption during pregnancy has consequences for child development during the first 3 years. The women were taken into the study during the first trimester of pregnancy and were seen every 4 weeks. Some 4.7% (353) of the total stated that they drank moderate quantities of alcohol every day; 275 of the 353 pregnant women stopped drinking during the first trimester of pregnancy or for a time, but 78 did not change their drinking habits in general. About 75% of the children were followed up to their 3rd birthday with examinations at birth, 6 weeks, and 9, 18 and 36 months. It was found that in growth and psychomotor development the exposed children did not differ from the control group. The number of minor and major congenital anomalies was not increased. In general, moderate alcohol consumption during pregnancy does not seem to have any markedly adverse influence on the later development of children. However, an upper limit for apparently safe alcohol consumption cannot be given.
基于对7525例妊娠前瞻性收集的数据,研究了孕期适度但每日饮酒是否会对儿童头3年的发育产生影响。这些女性在妊娠早期被纳入研究,每4周接受一次检查。总计约4.7%(353例)称她们每天饮用适量酒精;353例孕妇中有275例在妊娠早期或一段时间内停止饮酒,但78例总体上未改变饮酒习惯。约75%的儿童随访至3岁生日,分别在出生时、6周、9个月、18个月和36个月时接受检查。结果发现,在生长和精神运动发育方面,暴露组儿童与对照组儿童没有差异。轻微和严重先天性异常的数量没有增加。总体而言,孕期适度饮酒似乎对儿童后期发育没有明显的不利影响。然而,无法给出明显安全的酒精摄入量上限。