Forrest F, Florey C D, Taylor D, McPherson F, Young J A
Department of Epidemiology and Public Health, University of Dundee, Ninewells Hospital and Medical School.
BMJ. 1991 Jul 6;303(6793):22-6. doi: 10.1136/bmj.303.6793.22.
To determine the relation between mothers' self reported drinking habits before, during, and after pregnancy and infants' mental and motor development at 18 months of age.
Follow up study of all singleton live births born to primigravidas living in Dundee and booked into antenatal clinics from 1 May 1985 to 30 April 1986.
District of Dundee.
846 children aged 18 months, of whom 592 attended for assessment.
Scores on Bayley scales of infant mental and motor development.
For full term children, maternal alcohol consumption was not significantly related to any adverse effect on the children's mental or motor development measures at age 18 months. After confounding factors had been controlled for, alcohol consumption before pregnancy and after pregnancy was significantly related to better motor performance and mental performance.
Pregnant women probably need not abstain from alcohol altogether as no detectable adverse relation was found between the child's mental and physical development and the mother's weekly consumption at levels in excess of 100g absolute alcohol. However, to allow for a margin of safety and taking into account the findings of an earlier phase of this study on the immediate effects on the newborn, it is recommended that pregnant women should drink no more than eight units of alcohol a week, the equivalent of about one drink a day.
确定母亲在怀孕前、怀孕期间及产后自我报告的饮酒习惯与婴儿18个月时的智力和运动发育之间的关系。
对1985年5月1日至1986年4月30日居住在邓迪并在产前诊所登记的初产妇所生的所有单胎活产婴儿进行随访研究。
邓迪地区。
846名18个月大的儿童,其中592名接受了评估。
贝利婴儿智力和运动发育量表得分。
对于足月出生的儿童,母亲饮酒与18个月大儿童的智力或运动发育指标的任何不良影响均无显著关联。在控制混杂因素后,怀孕前和怀孕后的饮酒与更好的运动表现和智力表现显著相关。
由于未发现儿童的智力和身体发育与母亲每周超过100克纯酒精摄入量之间存在可检测到的不良关联,孕妇可能无需完全戒酒。然而,为了留出安全边际并考虑到本研究早期阶段关于对新生儿即时影响的研究结果,建议孕妇每周饮酒不超过8个单位,相当于每天约一杯酒。