内源性嗜亲性病毒在嵌合宿主的AKR胸腺淋巴细胞中未表达的证据。
Evidence that endogenous ecotropic virus is not expressed in AKR thymic lymphoid cells of chimeric hosts.
作者信息
Blank K J, Pincus T
出版信息
J Exp Med. 1980 Aug 1;152(2):458-62. doi: 10.1084/jem.152.2.458.
Abstract
AKR/J thymocytes derived from fetal liver cells do not produce virus when they differentiate in lethally irradiated B10.K mice, whereas spleen and bone marrow cells are virus producers. In contrast, B10.K thymocytes that differentiate in lethally irradiated AKR mice become virus producers. These results suggest that infection of the thymus in AKR mice is initiated in thymic stromal cells.
摘要
源自胎肝细胞的AKR/J胸腺细胞在经致死剂量照射的B10.K小鼠体内分化时不产生病毒，而脾细胞和骨髓细胞则是病毒产生者。相比之下，在经致死剂量照射的AKR小鼠体内分化的B10.K胸腺细胞成为病毒产生者。这些结果表明，AKR小鼠胸腺的感染始于胸腺基质细胞。
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