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内源性嗜亲性病毒在嵌合宿主的AKR胸腺淋巴细胞中未表达的证据。

Evidence that endogenous ecotropic virus is not expressed in AKR thymic lymphoid cells of chimeric hosts.

作者信息

Blank K J, Pincus T

出版信息

J Exp Med. 1980 Aug 1;152(2):458-62. doi: 10.1084/jem.152.2.458.

DOI:10.1084/jem.152.2.458
PMID:7400760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185939/
Abstract

AKR/J thymocytes derived from fetal liver cells do not produce virus when they differentiate in lethally irradiated B10.K mice, whereas spleen and bone marrow cells are virus producers. In contrast, B10.K thymocytes that differentiate in lethally irradiated AKR mice become virus producers. These results suggest that infection of the thymus in AKR mice is initiated in thymic stromal cells.

摘要

源自胎肝细胞的AKR/J胸腺细胞在经致死剂量照射的B10.K小鼠体内分化时不产生病毒，而脾细胞和骨髓细胞则是病毒产生者。相比之下，在经致死剂量照射的AKR小鼠体内分化的B10.K胸腺细胞成为病毒产生者。这些结果表明，AKR小鼠胸腺的感染始于胸腺基质细胞。

相似文献

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Evidence that endogenous ecotropic virus is not expressed in AKR thymic lymphoid cells of chimeric hosts.内源性嗜亲性病毒在嵌合宿主的AKR胸腺淋巴细胞中未表达的证据。
J Exp Med. 1980 Aug 1;152(2):458-62. doi: 10.1084/jem.152.2.458.
2
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The role of bone marrow and thymic elements in the initiation and spread of virus production in the AKR thymus.骨髓和胸腺成分在AKR胸腺中病毒产生的起始和传播中的作用。
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J Immunol. 1988 Sep 15;141(6):2181-6.
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引用本文的文献

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J Virol. 1989 May;63(5):2134-42. doi: 10.1128/JVI.63.5.2134-2142.1989.

本文引用的文献

1
"Spontaneous" leukemia developing in C3H mice following inoculation in infancy, with AK-leukemic extracts, or AK-embrvos.在婴儿期接种AK白血病提取物或AK胚胎后，C3H小鼠中发生的“自发性”白血病。
Proc Soc Exp Biol Med. 1951 Jan;76(1):27-32.
2
UNILATERAL HISTOGENESIS OF AKR THYMIC LYMPHOMA.Akr胸腺淋巴瘤的单侧组织发生
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Phenotypic alteration in retroviral gene expression by leukemia-resistant thymocytes differentiating in leukemia-susceptible recipients.白血病抗性胸腺细胞在白血病易感受体中分化时逆转录病毒基因表达的表型改变。
Cell. 1980 Jan;19(1):171-9. doi: 10.1016/0092-8674(80)90398-0.
4
Prevalence of type-C particles in visceral tissues of embryonic and newborn mice.胚胎和新生小鼠内脏组织中C型颗粒的患病率。
J Natl Cancer Inst. 1973 Oct;51(4):1171-5. doi: 10.1093/jnci/51.4.1171.
5
Studies of genetic transmission of murine leukemia virus by AKR mice. I. Crosses with Fv-1 n strains of mice.AKR小鼠对鼠白血病病毒的遗传传递研究。I. 与Fv-1 n系小鼠的杂交。
J Exp Med. 1972 Nov 1;136(5):1272-85. doi: 10.1084/jem.136.5.1272.
6
Quantitative studies of naturally occurring murine leukemia virus infection of AKR mice.对AKR小鼠自然发生的鼠白血病病毒感染的定量研究。
J Exp Med. 1972 Feb 1;135(2):429-36. doi: 10.1084/jem.135.2.429.
7
A major genetic locus affecting resistance to infection with murine leukemia viruses. I. Tissue culture studies of naturally occurring viruses.一个影响对鼠白血病病毒感染抗性的主要基因位点。I. 自然发生病毒的组织培养研究
J Exp Med. 1971 Jun 1;133(6):1219-33. doi: 10.1084/jem.133.6.1219.
8
Isolation of naturally occurring viruses of the murine leukemia virus group in tissue culture.在组织培养中分离鼠白血病病毒组的天然存在病毒。
J Virol. 1969 Feb;3(2):126-32. doi: 10.1128/JVI.3.2.126-132.1969.
9
Electron microscopic study of the mouse leukemia virus (Gross) in organs of mouse embryos from virus-injected and normal C3Hf parents.对来自注射病毒的和正常C3Hf亲代的小鼠胚胎器官中（格罗斯）小鼠白血病病毒的电子显微镜研究。
Cancer Res. 1967 Oct;27(10):1792-804.
10
Plaque assay techniques for murine leukemia viruses.小鼠白血病病毒的噬斑测定技术
Virology. 1970 Dec;42(4):1136-9. doi: 10.1016/0042-6822(70)90362-4.