Sakano K, Ishimaru K, Nakamura S
J Antibiot (Tokyo). 1980 Jul;33(7):683-9. doi: 10.7164/antibiotics.33.683.
An unidentified Streptomyces, designated as Strain H 1051-MY 10, was proved to produce viomycin and two new antibiotics. The new antibiotics were extracted from the cultured mycelia with acetone and transferred to ethyl acetate after acetone was removed in vacuo. The extracted antibiotics were separated into two components by alumina column chromatography and named carbazomycins A and B, because both antibiotics were proved to contain a carbazole nucleus. The molecular formulae of carbazomycins A and B were determined to be C16H17NO2 and C15H15NO2, respectively. Further, carbazomycin B was methylated with diazomethane to give carbazomycin A. Carbazomycins inhibited the growth of phytophathogenic fungi and further showed weak antibacterial and antiyeast activities.
一株未鉴定的链霉菌，命名为菌株H 1051-MY 10，被证明能产生紫霉素和两种新抗生素。新抗生素用丙酮从培养的菌丝体中提取，丙酮在真空中除去后转移至乙酸乙酯中。提取的抗生素通过氧化铝柱色谱法分离成两个组分，分别命名为咔唑霉素A和B，因为两种抗生素都被证明含有咔唑核。咔唑霉素A和B的分子式分别确定为C16H17NO2和C15H15NO2。此外，咔唑霉素B用重氮甲烷甲基化得到咔唑霉素A。咔唑霉素能抑制植物病原真菌的生长，还表现出较弱的抗菌和抗酵母活性。
