非那西丁尿酸，大鼠体内苯乙烯的一种新的尿液代谢物。
Phenaceturic acid, a new urinary metabolite of styrene in the rat.
作者信息
Delbressine L P, Ketelaars H C, Seutter-Berlage F, Smeets F L
出版信息
Xenobiotica. 1980 May;10(5):337-42. doi: 10.3109/00498258009033765.
PMID:7415215
Abstract
- After administration of styrene to rat, phenaceturic acid, a new metabolite, was isolated. After administration of d8-styrene to rat, deuterium-labelled phenaceturic acid was excreted in the urine. 2. Two metabolic pathways are proposed, based on mass spectra of the deuterium-labelled phenaceturic acid. 3. After a single dose of styrene (250 mg/kg), the excreted phenaceturic acid originating from styrene in the urine amounted to 1.4% dose.
摘要
- 将苯乙烯给予大鼠后，分离出一种新的代谢产物苯乙酰尿酸。将d8-苯乙烯给予大鼠后，氘标记的苯乙酰尿酸从尿中排出。2. 根据氘标记的苯乙酰尿酸的质谱提出了两条代谢途径。3. 单次给予苯乙烯（250毫克/千克）后，尿中源自苯乙烯的排出的苯乙酰尿酸量为给药剂量的1.4%。
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