Wilson P W, Garrison R J, Castelli W P, Feinleib M, McNamara P M, Kannel W B
Am J Cardiol. 1980 Oct;46(4):649-54. doi: 10.1016/0002-9149(80)90516-0.
Forth-three of 1,312 men aged 35 to 54 years in the Framingham Offspring Study had clinically recognized coronary heart disease at the initial examination. Twenty-six men in this group had previously had a myocardial infarction. Of 1,296 women in the same age range, only 11 had coronary disease and 3 a prior myocardial infarction. The prevalence of coronary heart disease in men was strongly associated with age, smoking, high density lipoprotein (HDL), low density lipoprotein (LDL) and total cholesterol using univariate analyses. When multivariate logistic regression analysis was used, age, smoking and HDL and LDL cholesterol retained their significant associatin with coronary heart disease. The total cholesterol/HDL cholesterol ratio was also strongly associated with coronary heart disease in the multivariate analysis. It is concluded that both HDL and LDL cholesterol are strongly and independently associated with the prevalence of coronary heart disease, whereas the level of very low density lipoprotein cholesterol makes no statistically significant independent contribution.
在弗雷明汉后代研究中，1312名年龄在35至54岁的男性中，有43人在初次检查时被临床诊断为冠心病。该组中有26名男性曾患过心肌梗死。在同一年龄段的1296名女性中，只有11人患有冠心病，3人曾患心肌梗死。单因素分析显示，男性冠心病患病率与年龄、吸烟、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和总胆固醇密切相关。当使用多因素逻辑回归分析时，年龄、吸烟以及HDL和LDL胆固醇与冠心病仍保持显著相关性。在多因素分析中，总胆固醇/HDL胆固醇比值也与冠心病密切相关。结论是，HDL和LDL胆固醇均与冠心病患病率密切且独立相关，而极低密度脂蛋白胆固醇水平在统计学上没有显著的独立贡献。
