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24种抗菌剂对空肠弯曲菌胎儿亚种的抑菌和杀菌活性。

Bacteriostatic and bactericidal activities of 24 antimicrobial agents against Campylobacter fetus subsp. jejuni.

作者信息

Vanhoof R, Gordts B, Dierickx R, Coignau H, Butzler J P

出版信息

Antimicrob Agents Chemother. 1980 Jul;18(1):118-21. doi: 10.1128/AAC.18.1.118.

Abstract

The bacteriostatic and bactericidal activities of 24 antimicrobial agents were tested with the Dynatech MIC 2000 system against 86 strains of Campylobacter fetus subsp. jejuni from human sources. The penicillins (penicillin G, ampicillin, amoxycillin, carbenicillin) had poor activity. Ampicillin and amoxycillin were equally active. Cefotaxime revealed a rather good activity. Erythromycin, gentamicin, tobramycin, amikacin, and furazolidone were the most active compounds. Two strains (2.3%) were resistant to erythromycin. One strain (1.2%) was completely resistant to tobramycin. The tetracyclines (tetracyline, doxycycline, minocycline) were generally effective, but 8% of the strains were totally resistant to them. Minocycline was the most active. Chloramphenicol, thiamphenicol, and clindamycin had good activity. The bacteriostatic and bactericidal distributions for colistin, nalidixic acid, and metronidazole were broad.

摘要

采用Dynatech MIC 2000系统对24种抗菌药物针对86株来自人类的空肠弯曲菌胎儿亚种的抑菌和杀菌活性进行了测试。青霉素类(青霉素G、氨苄西林、阿莫西林、羧苄西林)活性较差。氨苄西林和阿莫西林活性相当。头孢噻肟显示出较好的活性。红霉素、庆大霉素、妥布霉素、阿米卡星和呋喃唑酮是活性最强的化合物。两株菌株(2.3%)对红霉素耐药。一株菌株(1.2%)对妥布霉素完全耐药。四环素类(四环素、多西环素、米诺环素)总体有效,但8%的菌株对其完全耐药。米诺环素活性最强。氯霉素、甲砜霉素和克林霉素活性良好。黏菌素、萘啶酸和甲硝唑的抑菌和杀菌分布范围较广。

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本文引用的文献

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Campylobacter enteritis: a "new" disease.弯曲杆菌肠炎:一种“新”疾病。
Br Med J. 1977 Jul 2;2(6078):9-11. doi: 10.1136/bmj.2.6078.9.
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Campylobacter enteritis.弯曲杆菌肠炎
Acta Paediatr Belg. 1979 Apr-Jun;32(2):89-94.
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Campylobacter enteritis in children.儿童弯曲杆菌肠炎
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[Campylobacter and enteritis].[弯曲杆菌与肠炎]
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