Cooper B T, Holmes G K, Ferguson R, Thompson R A, Allan R N, Cooke W T
Gastroenterology. 1980 Nov;79(5 Pt 1):801-6.
Eight adult female patients suffering from abdominal pain and chronic diarrhea which was often incapacitating and frequently nocturnal, had dramatic relief on a gluten-free diet and return of symptoms after gluten challenge. Previous nonspecific measures and a milk-free diet were ineffective. Multiple jejunal biopsies showed minor, but significant changes in cellularity which returned to normal on the gluten-free diet. Apart from a slight increase in jejunal cellularity, no immunological abnormalities were found after gluten challenge. Steatorrhea or other biochemical defects, common in celiac disease, were not found. It was concluded that these patients had a gluten-sensitive diarrhea, but had no evidence of celiac disease.
八名成年女性患者患有腹痛和慢性腹泻，这种腹泻常常使人衰弱且频繁在夜间发作，采用无麸质饮食后症状显著缓解，而在接受麸质激发试验后症状复发。先前的非特异性措施和无奶饮食均无效。多次空肠活检显示细胞数量有轻微但显著的变化，在无麸质饮食后恢复正常。除空肠细胞数量略有增加外，麸质激发试验后未发现免疫异常。未发现乳糜泻常见的脂肪泻或其他生化缺陷。结论是这些患者患有麸质敏感性腹泻，但无乳糜泻的证据。
