Prinz P N, Roehrs T A, Vitaliano P P, Linnoila M, Weitzman E D
J Clin Endocrinol Metab. 1980 Oct;51(4):759-64. doi: 10.1210/jcem-51-4-759.
The acute and chronic effects of alcohol and alcohol withdrawal on sleep patterns and plasma GH and cortisol fluctuations occurring during sleep were studied. Five healthy men, aged 21-26 yr, consumed a placebo drink for 3 baseline nights, alcohol (0.8 g/kg) for 9 nights, and a placebo drink on final withdrawal night. All-night polygraphic sleep recordings and blood samples (every 20 min with a venous catheter) were collected for 1 placebo, 1 acute alcohol, 1 chronic alcohol (night 9), and 1 alcohol withdrawal night. Acute and chronic alcohol consumption reduced rapid eye movement sleep nonsignificantly during the first half of the night, whereas slow wave sleep (stages 3 and 4) was increased significantly after acute alcohol, returning to baseline values on the chronic alcohol night. On the withdrawal night, rapid eye movement sleep and slow wave sleep were not significantly different from placebo sleep. Alcohol significantly suppressed plasma GH values (70-75%) on acute and chronic nights. All measures of GH, including total integral for bedtime hours, mean hourly rate, and peak level, were similarly affected by alcohol. GH returned to placebo values on the withdrawal night. Measures of nighttime plasma cortisol were not significantly altered by alcohol or alcohol withdrawal at this dose level.
研究了酒精及其戒断对睡眠模式以及睡眠期间血浆生长激素（GH）和皮质醇波动的急性和慢性影响。5名年龄在21 - 26岁的健康男性，在3个基线夜晚饮用安慰剂饮料，9个夜晚饮用酒精（0.8克/千克），在最后戒断夜晚饮用安慰剂饮料。在1个安慰剂夜晚、1个急性酒精摄入夜晚、1个慢性酒精摄入夜晚（第9晚）和1个酒精戒断夜晚收集整夜多导睡眠记录和血样（通过静脉导管每20分钟采集一次）。急性和慢性酒精摄入在前半夜非显著降低快速眼动睡眠，而急性酒精摄入后慢波睡眠（3期和4期）显著增加，在慢性酒精摄入夜晚恢复到基线值。在戒断夜晚，快速眼动睡眠和慢波睡眠与安慰剂睡眠无显著差异。酒精在急性和慢性摄入夜晚显著抑制血浆GH值（70 - 75%）。酒精对GH的所有测量指标，包括就寝时间的总积分、每小时平均速率和峰值水平，产生类似影响。GH在戒断夜晚恢复到安慰剂值。在该剂量水平下，酒精或酒精戒断对夜间血浆皮质醇测量指标无显著改变。
