成人卵黄样黄斑变性：诊断与自然病程。

Epstein G A, Rabb M F

Br J Ophthalmol. 1980 Oct;64(10):733-40. doi: 10.1136/bjo.64.10.733.

True vitelliform dystrophy rarely appears in the adult population. We describe 10 cases in adults of bilateral vitelliform lesions clinically mistaken for Best's disease. Fluorescein angiography is a useful tool in distinguishing this dystrophy from Best's disease or other diseases. The angiographic findings suggest pigment epithelial disease. Adult vitelliform degeneration may lead to dry atrophic macular degeneration in a similar fashion as macular drusen. Symptoms and visual findings in these patients are fairly stable, and may be only slowly progressive in spite of ophthalmoscopic and fluorescein angiographic changes over a period of years. The electro-oculogram is useful in separating adult vitelliform macular degeneration from true vitelliform dystrophy.

真正的卵黄样营养不良在成人中很少出现。我们描述了10例成人双侧卵黄样病变，临床上误诊为Best病。荧光素血管造影是区分这种营养不良与Best病或其他疾病的有用工具。血管造影结果提示色素上皮疾病。成人卵黄样变性可能以与黄斑玻璃疣类似的方式导致干性萎缩性黄斑变性。这些患者的症状和视力表现相当稳定，尽管多年来眼底镜和荧光素血管造影有变化，但可能仅缓慢进展。眼电图有助于将成人卵黄样黄斑变性与真正的卵黄样营养不良区分开来。