Rasp F L, Clawson C C, Hoidal J R, Repine J E
Am Rev Respir Dis. 1978 Dec;118(6):979-86. doi: 10.1164/arrd.1978.118.6.979.
The nylon fiber adherence in vitro of alveolar macrophages (AM) from cigarette smokers was uniformly decreased. The mean adherence of AM from 16 cigarette smokers was 53 +/- 3.0 per cent, compared to a mean adherence of 77.2 +/- 1.7 per cent for AM from control nonsmokers. The defect was not present after the subjects quit smoking, was not a result of factors in lavage fluids from smokers, and was not apparent in polymorphonuclear leukocytes. The morphologic features of the surface of AM were examined with scanning electron microscopy to determine whether morphologic changes paralleled the decreased adherence of AM from smokers. Marked alterations in the surface of AM from cigarette smokers, which could affect the ability of AM to adhere optimally, were demonstrated before attachment to the fiber. In summary, there exists a reversible, intrinsic defect in the structure and adherence of AM from cigarette smokers that may influence their function and may accout, in part, for the increased yield of AM from the lavage fluid of cigarette smokers.
吸烟者肺泡巨噬细胞（AM）的尼龙纤维体外黏附力普遍下降。16名吸烟者的AM平均黏附率为53±3.0%，而对照非吸烟者的AM平均黏附率为77.2±1.7%。受试者戒烟后该缺陷消失，并非吸烟者灌洗液中因素所致，且在多形核白细胞中不明显。用扫描电子显微镜检查AM表面的形态特征，以确定形态学变化是否与吸烟者AM黏附力下降平行。在吸烟者的AM附着于纤维之前，就已显示其表面有明显改变，这可能会影响AM的最佳黏附能力。总之，吸烟者的AM在结构和黏附方面存在可逆的内在缺陷，这可能会影响其功能，部分解释了吸烟者灌洗液中AM产量增加的原因。
