阿莫西林在脑脊液中的渗透情况。
Penetration of amoxicillin into cerebrospinal fluid.
作者信息
Strausbaugh L J, Girgis N I, Mikhail I A, Edman D C, Miner W F, Yassin M W
出版信息
Antimicrob Agents Chemother. 1978 Dec;14(6):899-902. doi: 10.1128/AAC.14.6.899.
Abstract
The penetration of amoxicillin into cerebrospinal fluid (CFS) in the presence of meningeal inflammation was evaluated in patients with tuberculous meningitis. Serum and CSF concentrations of amoxicillin were measured at 2 h in nine patients who received a 1-g oral dose and at 1.5 and 4 h in ten patients who received a 2-g intravenous injection of sodium amoxicillin. After the oral dose, CSF concentrations ranged from 0.1 to 1.5 mug/ml. After the intravenous injection, CSF concentrations ranged from 2.9 to 40.0 mug/ml at 1.5 h and from 2.6 to 27.0 mug/ml at 4 h. These data on penetration suggest that parenterally administered sodium amoxicillin may be of value in the therapy of acute bacterial meningitis.
摘要
在患有结核性脑膜炎的患者中评估了在脑膜炎症存在的情况下阿莫西林进入脑脊液（CFS）的情况。对9名接受1g口服剂量的患者在2小时时测量了血清和脑脊液中阿莫西林的浓度，对10名接受2g阿莫西林钠静脉注射的患者在1.5小时和4小时时测量了血清和脑脊液中阿莫西林的浓度。口服给药后，脑脊液浓度范围为0.1至1.5μg/ml。静脉注射后，1.5小时时脑脊液浓度范围为2.9至40.0μg/ml，4小时时脑脊液浓度范围为2.6至27.0μg/ml。这些关于药物渗透的数据表明，静脉注射的阿莫西林钠可能对急性细菌性脑膜炎的治疗有价值。
相似文献
1
Penetration of amoxicillin into cerebrospinal fluid.阿莫西林在脑脊液中的渗透情况。
Antimicrob Agents Chemother. 1978 Dec;14(6):899-902. doi: 10.1128/AAC.14.6.899.
2
Amoxicillin entry into human cerebrospinal fluid: comparison with ampicillin.阿莫西林进入人脑脊液的情况：与氨苄西林的比较。
Antimicrob Agents Chemother. 1978 Oct;14(4):531-2. doi: 10.1128/AAC.14.4.531.
3
Treatment of bacterial meningitis with intravenous amoxicillin.静脉注射阿莫西林治疗细菌性脑膜炎。
Antimicrob Agents Chemother. 1979 Aug;16(2):171-5. doi: 10.1128/AAC.16.2.171.
4
[Penetration of amoxicillin into the cerebrospinal fluid].[阿莫西林在脑脊液中的穿透情况]
Arch Sci Med (Torino). 1981 Jan-Mar;138(1):33-5.
5
Penetration of amoxicillin and potassium clavulanate into the cerebrospinal fluid of patients with inflamed meninges.阿莫西林和克拉维酸钾在脑膜炎患者脑脊液中的渗透情况。
Antimicrob Agents Chemother. 1986 Sep;30(3):481-4. doi: 10.1128/AAC.30.3.481.
6
Clinicopharmacological evaluation of amoxicillin and probenecid against bacterial meningitis.阿莫西林与丙磺舒治疗细菌性脑膜炎的临床药理学评价
Antimicrob Agents Chemother. 1979 Sep;16(3):346-52. doi: 10.1128/AAC.16.3.346.
7
Levels of antibiotic in human blood and interstitial fluid after oral administration of bacampicillin or phenoxymethyl penicillin and intravenous administration of amoxicillin or ampicillin.口服巴卡西林或苯氧甲基青霉素以及静脉注射阿莫西林或氨苄西林后人体血液和组织液中的抗生素水平。
Rev Infect Dis. 1981 Jan-Feb;3(1):121-4. doi: 10.1093/clinids/3.1.121.
8
[Factors of meningeal diffusion of amoxicillin and ampicillin at the acute phase of purulent meningitis in children].[儿童化脓性脑膜炎急性期阿莫西林和氨苄西林的脑膜扩散因素]
Arch Fr Pediatr. 1985 Feb;42(2):129-32.
9
Amoxycillin trihydrate (Ibeamox) in the treatment of pyogenic meningitis-a preliminary report.三水阿莫西林（益萨林）治疗化脓性脑膜炎——初步报告
J Pak Med Assoc. 1977 May;27(5):323-4.
10
Pharmacokinetics of amoxicillin: dose dependence after intravenous, oral, and intramuscular administration.阿莫西林的药代动力学：静脉注射、口服和肌肉注射后的剂量依赖性。
Antimicrob Agents Chemother. 1977 Jan;11(1):132-41. doi: 10.1128/AAC.11.1.132.
引用本文的文献
1
Pharmacokinetics of antibacterial agents in the CSF of children and adolescents.抗菌药物在儿童和青少年脑脊液中的药代动力学。
Paediatr Drugs. 2013 Apr;15(2):93-117. doi: 10.1007/s40272-013-0017-5.
2
Prevention of surgical site infection after open prosthetic inguinal hernia repair: efficacy of parenteral versus oral prophylaxis with amoxicillin-clavulanic acid in a randomized clinical trial.开放性人工腹股沟疝修补术后手术部位感染的预防：阿莫西林-克拉维酸肠外预防与口服预防在一项随机临床试验中的疗效
World J Surg. 2005 Jun;29(6):794-9. doi: 10.1007/s00268-005-7689-0.
3
Clinical pharmacokinetics of cerebrospinal fluid.脑脊液的临床药代动力学
Clin Pharmacokinet. 1982 Jul-Aug;7(4):312-35. doi: 10.2165/00003088-198207040-00003.
4
Amoxycillin injectable: a review of its antibacterial spectrum, pharmacokinetics and therapeutic use.注射用阿莫西林：抗菌谱、药代动力学及治疗用途综述
Drugs. 1979 Sep;18(3):169-84. doi: 10.2165/00003495-197918030-00001.
本文引用的文献
1
Treatment of pneumococcic meningitis with penicillin compared with penicillin plus aureomycin; studies including observations on an apparent antagonism between penicillin and aureomycin.用青霉素与青霉素加金霉素治疗肺炎球菌性脑膜炎的比较研究；包括对青霉素与金霉素之间明显拮抗作用的观察。
AMA Arch Intern Med. 1951 Oct;88(4):489-94. doi: 10.1001/archinte.1951.03810100073006.
2
Antibiotic antagonism in bacterial meningitis.细菌性脑膜炎中的抗生素拮抗作用。
Antimicrob Agents Chemother (Bethesda). 1967;7:218-24.
3
Simplified, accurate method for antibiotic assay of clinical specimens.临床标本抗生素检测的简化、准确方法。
Appl Microbiol. 1966 Mar;14(2):170-7. doi: 10.1128/am.14.2.170-177.1966.
4
Levels of amoxicillin and ampicillin in human serum and interstitial fluid.
J Infect Dis. 1974 Jun;129(0):suppl:S146-8. doi: 10.1093/infdis/129.supplement_2.s146.
5
Laboratory evaluation of amoxicillin.阿莫西林的实验室评估
J Infect Dis. 1974 Jun;129(0):suppl:S139-45. doi: 10.1093/infdis/129.supplement_2.s139.
6
Antimicrobial activity and human pharmacology of amoxicillin.阿莫西林的抗菌活性与人体药理学
J Infect Dis. 1974 Jun;129(0):suppl:S123-31. doi: 10.1093/infdis/129.supplement_2.s123.
7
Amoxicillin in the treatment of infections of the lower respiratory tract.阿莫西林治疗下呼吸道感染
J Infect Dis. 1974 Jun;129(0):suppl:S189-93. doi: 10.1093/infdis/129.supplement_2.s189.
8
Comparative effects of amoxycillin and ampicillin in the treatment of experimental mouse infections.阿莫西林与氨苄西林治疗实验性小鼠感染的对比效果
Antimicrob Agents Chemother. 1975 Feb;7(2):179-85. doi: 10.1128/AAC.7.2.179.
9
Comparative effects of amoxycillin and ampicillin on the morphology of Escherichia coli in vivo and correlation with activity.阿莫西林和氨苄西林对体内大肠杆菌形态的比较作用及其与活性的相关性
Antimicrob Agents Chemother. 1977 Dec;12(6):736-44. doi: 10.1128/AAC.12.6.736.
Zotero 插件