Csángó P A, Upsahl M T, Romberg O, Kornstad L, Sarov I
Department of Microbiology, Vest-Agder Central Hospital, Kristiansand, Norway.
Clin Rheumatol. 1987 Sep;6(3):384-90. doi: 10.1007/BF02206837.
Demonstration of chlamydial antibodies in patients with ankylosing spondylitis (AS) could show an etiological role of Chlamydia trachomatis in this condition. We studied serum specimens from 50 HLA-B27 positive patients with AS (Group I), 34 HLA-B27 positive patients with other rheumatic diseases (Group II), 67 HLA-B27 positive healthy blood donors (Group III) and 37 healthy untyped blood donors. (Group IV). Measured by an immunoperoxidase assay (IPA) chlamydial IgA (titre greater than or equal to 1:20) was more prevalent in the HLA-B27 positive persons than in the healthy controls not selected for HLA-group (Groups I + II + III vs IV : p less than 0.02). Chlamydia trachomatis IgA-IPA containing sera also had specific IgG-IPA antibodies (greater than or equal to 1:80) in 29 (96%) out of 30 sera from HLA-B27 positive individuals and controls. Conversely, 45% of specific IgG-positive (greater than or equal to 1:80) AS sera, 27.7% sera in Group II, 39.4% Group III sera vs. 11.1% of sera in Group IV had concomitant chlamydial IgA (greater than or equal to 1:20). The differences in the prevalence of specific IgA were statistically significant: Group I vs. IV : p less than 0.01; Group III vs. IV :p less than 0.05 and Gr. I + II + III vs. IV: p less than 0.05. Our data suggest an enhanced antibody production against Chlamydia trachomatis among the HLA-B27 positive individuals whether they have AS or are healthy.
在强直性脊柱炎（AS）患者中检测衣原体抗体，可能显示沙眼衣原体在该病中的病因学作用。我们研究了50例HLA - B27阳性的AS患者（第一组）、34例HLA - B27阳性的其他风湿性疾病患者（第二组）、67例HLA - B27阳性的健康献血者（第三组）以及37例未分型的健康献血者（第四组）的血清标本。通过免疫过氧化物酶测定法（IPA）检测发现，衣原体IgA（滴度大于或等于1:20）在HLA - B27阳性人群中比未按HLA分组的健康对照人群更常见（第一组 + 第二组 + 第三组与第四组比较：p小于0.02）。在来自HLA - B27阳性个体和对照的30份血清中，29份（96%）含有沙眼衣原体IgA - IPA的血清也具有特异性IgG - IPA抗体（大于或等于1:80）。相反，45%的特异性IgG阳性（大于或等于1:80）的AS血清、27.7%的第二组血清、39.4%的第三组血清与11.1%的第四组血清同时伴有衣原体IgA（大于或等于1:20）。特异性IgA流行率的差异具有统计学意义：第一组与第四组比较：p小于0.01；第三组与第四组比较：p小于0.05；第一组 + 第二组 + 第三组与第四组比较：p小于0.05。我们的数据表明，无论HLA - B27阳性个体患有AS还是健康，他们针对沙眼衣原体的抗体产生均增强。
