药物输注治疗的结肠癌患者的临床反应及5-氟尿嘧啶的血浆水平
Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion.
作者信息
Hillcoat B L, McCulloch P B, Figueredo A T, Ehsan M H, Rosenfeld J M
出版信息
Br J Cancer. 1978 Dec;38(6):719-24. doi: 10.1038/bjc.1978.278.
Abstract
Concentrations of 5-fluorouracil (FU) were measured in the plasma of patients receiving i.v. infusions of the drug for 5 days as treatment for adenocarcinoma of the gastrointestinal tract. Concentrations of FU varied widely in many patients. Concentration of drug X time of infusion (C X t values) were calculated. Patients showing a partial response or stabilization of disease had significantly higher C X t values than non-responders. Methyl CCNU did not affect the C X t values of FU. Determination of the plasma concentration of FU would allow the dose of the drug to be adjusted to maintain high concentrations of FU in the plasma. Our data suggest that such high concentrations would increase the response rate in this disease.
摘要
对接受静脉输注5-氟尿嘧啶（FU）5天以治疗胃肠道腺癌的患者血浆中的FU浓度进行了测量。许多患者的FU浓度差异很大。计算了药物浓度X输注时间（C×t值）。显示部分缓解或疾病稳定的患者的C×t值显著高于无反应者。甲基CCNU不影响FU的C×t值。测定FU的血浆浓度将有助于调整药物剂量，以维持血浆中高浓度的FU。我们的数据表明，如此高的浓度将提高该疾病的缓解率。
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