Influence of once-daily administration of beta-adrenoceptor antagonists on arterial pressure and its variability.

Intra-arterial pressure was recorded over 24 h in hypertensive patients before and during long-term treatment with beta-adrenoceptor antagonists given once daily under standardised conditions. Arterial pressure was reduced throughout the 24 h after the last dose as was variability of pressure during physical activity; variability during sleep and rest did not change significantly.