Abrass C K, Border W A, Hepner G
Clin Exp Immunol. 1980 May;40(2):292-8.
Circulating immune complexes have been described in viral hepatitis and primary biliary cirrhosis but their significance is unclear. Seventy-three patients with acute and chronic liver diseases were evaluated to determine the specificity of immune complex detection for a given liver disease. Immune complexes were measured by the fluid- and solid-phase Clq-binding assays. They were demonstrated frequently in all patients with liver disease, including those with viral hepatitis, alcoholic cirrhosis, chronic active and persistent hepatitis, drug-induced hepatitis and hepatic metastases. The presence of immune complexes was not specific for a given type of liver disease and did not correlate with hepatic dysfunction. We conclude that the detection of immune complexes is of no apparent diagnostic use in liver disease. Further evaluation of the antigen-antibody composition would be required to determine any pathogenic significance of the detected circulating immune complexes.
循环免疫复合物在病毒性肝炎和原发性胆汁性肝硬化中已有报道，但其意义尚不清楚。对73例急慢性肝病患者进行评估，以确定免疫复合物检测对特定肝病的特异性。通过液相和固相Clq结合试验检测免疫复合物。在所有肝病患者中均频繁检测到免疫复合物，包括病毒性肝炎、酒精性肝硬化、慢性活动性和持续性肝炎、药物性肝炎及肝转移患者。免疫复合物的存在并非特定类型肝病所特有，且与肝功能障碍无关。我们得出结论，免疫复合物检测在肝病中无明显诊断价值。需要进一步评估抗原-抗体组成，以确定检测到的循环免疫复合物的任何致病意义。
