Menke Thomas, Niklowitz Petra, Reinehr Thomas, de Sousa Gideon John, Andler Werner
Vestische Kinderklinik Datteln, Universität Witten/Herdecke, Dr-Friedrich-Steiner-Strasse 5, DE-45711 Datteln, Germany.
Horm Res. 2004;61(4):153-8. doi: 10.1159/000075670. Epub 2003 Dec 18.
In hyperthyroidism, increased oxygen consumption and free radical production in the stimulated respiratory chain leads to oxidative stress. Apart from its antioxidative function, coenzyme Q10 (CoQ10) is involved in electron transport in the respiratory chain. The aim of this study was to determine whether there is a correlation between an increased respiratory chain activity and the state of CoQ10 in children with hyperthyroidism.
The CoQ10 plasma concentration was measured by high-performance liquid chromatography in 12 children with hyperthyroidism before and after treatment.
In the hyperthyroid state, the plasma level of CoQ10 was significantly decreased in comparison with the level in the euthyroid state. The correction of the hyperthyroid state resulted in a normalization of the CoQ10 level.
Plasma CoQ10 deficiency appears to be related to the stimulated respiratory chain activity in children with hyperthyroidism.
在甲状腺功能亢进症中，受刺激的呼吸链中氧消耗增加和自由基产生导致氧化应激。除了其抗氧化功能外，辅酶Q10（CoQ10）还参与呼吸链中的电子传递。本研究的目的是确定甲状腺功能亢进症患儿呼吸链活性增加与CoQ10状态之间是否存在相关性。
采用高效液相色谱法测定12例甲状腺功能亢进症患儿治疗前后的血浆CoQ10浓度。
与甲状腺功能正常状态相比，甲状腺功能亢进状态下CoQ10的血浆水平显著降低。甲状腺功能亢进状态的纠正导致CoQ10水平正常化。
血浆CoQ10缺乏似乎与甲状腺功能亢进症患儿受刺激的呼吸链活性有关。
