Higenbottam T, Cochrane G M, Clark T J, Turner D, Millis R, Seymour W
Thorax. 1980 Aug;35(8):581-5. doi: 10.1136/thx.35.8.581.
Ten patients with ulcerative colitis, all of whom were non-smokers, presented with a productive cough. In six, the chest radiography was normal and cough was the only symptom; three of these patients had a minor obstructive ventilatory defect on testing. Four patients complained of exertional dyspnoea and had both an abnormal chest radiograph with bilateral pulmonary shadows and a mixed obstructive and restrictive ventilatory defect. Bronchial epithelial biopsies from four patients (two with and two without pulmonary shadows) revealed basal reserve cell hyperplasia, basement membrane thickening, and submucosal inflammation, changes more usually associated with cigarette smoking. Inhaled beclomethasone diproprionate relieved cough in seven patients. The occurrence of airway epithelial disease in association with ulcerative colitis raises the possibility of a systemic mechanism affecting both bronchial and colonic epithelium. It does not seem likely that sulphasalazine was the cause of the pulmonary syndrome in these subjects.
10名溃疡性结肠炎患者均为非吸烟者，均出现咳痰。其中6人胸部X光检查正常，咳嗽是唯一症状；这些患者中有3人在检查时存在轻度阻塞性通气功能障碍。4名患者主诉劳力性呼吸困难，胸部X光检查异常，有双侧肺部阴影，存在混合性阻塞性和限制性通气功能障碍。4名患者（2名有肺部阴影，2名无肺部阴影）的支气管上皮活检显示基底储备细胞增生、基底膜增厚和黏膜下炎症，这些变化通常与吸烟有关。吸入丙酸倍氯米松使7名患者的咳嗽得到缓解。气道上皮疾病与溃疡性结肠炎相关的发生提示存在一种影响支气管和结肠上皮的全身性机制。柳氮磺胺吡啶似乎不太可能是这些患者肺部综合征的病因。
