Alexander T J, Thornton K, Boon G, Lysons R J, Gush A F
Vet Rec. 1980 Feb 9;106(6):114-9. doi: 10.1136/vr.106.6.114.
A field trial was conducted to assess the value of medicated early weaning for obtaining pigs free from some of the pathogens endemic in their herd of origin. The trial comprised 51 sows from a closed herd, which were farrowed in an isolated farrowing house in seven separate groups. The sows in each group were bred at the same time and induced to farrow on the same day. Their thriftiest piglets were weaned at five days of age and moved to an isolated early-weaning unit. At about six weeks of age they were moved to one of three isolated grow-out units where they were held to slaughter weight. Sows in five of the groups were dosed with high levels of tiamulin and trimethoprim-sulphonamide preparations from their entry into the farrowing house until their biggest piglets were weaned. Their piglets were dosed with similar drugs from birth until 10 days of age. The first and seventh groups of sows and their litters were not medicated. Tests were carried out on pigs aged five to 11 weeks, on slaughter pigs, and on pigs which died or were killed at different ages, for Mycoplasma hyopneumoniae, Bordetella bronchiseptica and colonic treponemes, which were readily detectable in the herd of origin. No evidence could be found of mycoplasma or bordetella. Colonic treponemes were recovered from some of the pigs at slaughter, but not from younger pigs. Thirty-seven boars and gilts from the medicated groups were introduced into 11 herds thought to be free of enzootic pneumonia and 13 were introduced into three herds which had enzootic pneumonia. No subsequent signs of enzootic pneumonia were noted in 10 of the enzootic pneumonia-free herds.
进行了一项田间试验,以评估药物早期断奶对于培育出无其原种猪群中某些地方性病原体的仔猪的价值。该试验包括来自一个封闭猪群的51头母猪,它们在一个隔离的产仔舍中产仔,分为七个独立的组。每组母猪同时配种,并在同一天诱导分娩。它们最健壮的仔猪在5日龄时断奶,并转移到一个隔离的早期断奶单元。在大约6周龄时,它们被转移到三个隔离的育肥单元之一,饲养至屠宰体重。五组母猪从进入产仔舍到其最大的仔猪断奶期间,投喂高剂量的泰妙菌素和甲氧苄啶-磺胺制剂。它们的仔猪从出生到10日龄投喂类似药物。第一组和第七组母猪及其仔猪未用药。对5至11周龄的猪、屠宰猪以及在不同年龄死亡或被宰杀的猪进行了检测,检测对象为猪肺炎支原体、支气管败血波氏杆菌和结肠密螺旋体,这些病原体在原种猪群中很容易检测到。未发现支原体或波氏杆菌的迹象。在一些屠宰猪中检测到结肠密螺旋体,但在幼猪中未检测到。来自用药组的37头公猪和后备母猪被引入11个被认为无地方性肺炎的猪群,13头被引入三个有地方性肺炎的猪群。在10个无地方性肺炎的猪群中,未发现随后出现地方性肺炎的迹象。