暴发性病毒性肝炎中的门静脉高压
Portal hypertension in fulminant viral hepatitis.
作者信息
Lebrec D, Nouel O, Bernuau J, Rueff B, Benhamou J P
出版信息
Gut. 1980 Nov;21(11):962-4. doi: 10.1136/gut.21.11.962.
Abstract
The gradient between wedged and free hepatic venous pressures were measured in 10 unselected adult patients suffering from fulminant viral hepatitis. The gradient was increased in all the studied patients, ranging from 0.9 to 2.1 kPa; this finding indicates that portal hypertension was present in all these cases. Ascites was present in all the five patients having a gradient about 1.5 kPa and affected only two of the five patients having a gradient below 1.5 kPa; this observation suggests that portal hypertension plays a role in the mechanism of ascites in fulminant viral hepatitis. Portal hypertension in fulminant viral hepatitis is likely to be the consequence of an intrahepatic block due to massive necrosis of the liver cells.
摘要
对10例未经过挑选的暴发性病毒性肝炎成年患者测量了肝静脉楔压与自由肝静脉压之间的梯度。所有研究患者的梯度均升高，范围为0.9至2.1 kPa；这一发现表明所有这些病例均存在门静脉高压。梯度约为1.5 kPa的所有5例患者均出现腹水，而梯度低于1.5 kPa的5例患者中只有2例出现腹水；这一观察结果提示门静脉高压在暴发性病毒性肝炎腹水形成机制中起作用。暴发性病毒性肝炎中的门静脉高压很可能是肝细胞大量坏死导致肝内阻塞的结果。
相似文献
1
Portal hypertension in fulminant viral hepatitis.暴发性病毒性肝炎中的门静脉高压
Gut. 1980 Nov;21(11):962-4. doi: 10.1136/gut.21.11.962.
2
Portal hypertension and ascites in acute hepatitis: clinical, hemodynamic and histological correlations.急性肝炎中的门静脉高压和腹水：临床、血流动力学及组织学相关性
Hepatology. 1989 Oct;10(4):482-7. doi: 10.1002/hep.1840100414.
3
Relationship between degree of portal hypertension and liver histologic lesions in patients with alcoholic cirrhosis. Effect of acute alcoholic hepatitis on portal hypertension.
Dig Dis Sci. 1987 Apr;32(4):337-43. doi: 10.1007/BF01296284.
4
Portal pressure in patients with exudative ascites in the course of acute hepatitis B.急性乙型肝炎病程中渗出性腹水患者的门静脉压力
Liver. 1991 Aug;11(4):206-10. doi: 10.1111/j.1600-0676.1991.tb00518.x.
5
Albumin gradient and portal vein velocity in severe viral hepatitis patients complicated with ascites.
Hepatogastroenterology. 2000 Nov-Dec;47(36):1700-2.
6
Effect of viral suppression on hepatic venous pressure gradient in hepatitis C with cirrhosis and portal hypertension.病毒抑制对丙型肝炎肝硬化伴门静脉高压患者肝静脉压力梯度的影响。
J Viral Hepat. 2017 Oct;24(10):823-831. doi: 10.1111/jvh.12706. Epub 2017 Apr 10.
7
Portal hypertension in chronic hepatitis--comparative manometric and clinico-chemical examinations.
Klin Wochenschr. 1980 Feb 15;58(4):207-8. doi: 10.1007/BF01476780.
8
Transient intrahepatic portal hypertension. A case report.
Digestion. 1981;21(3):140-2. doi: 10.1159/000198554.
9
The value of serum-ascites albumin gradient for the determination of portal hypertension in the diagnosis of ascites.血清腹水白蛋白梯度在腹水诊断中用于确定门静脉高压的价值。
Hepatogastroenterology. 2001 Jan-Feb;48(37):166-8.
10
Measurement of intrahepatic pressure as an index of hepatic sinusoidal pressure.测量肝内压力作为肝窦压力的指标。
Am J Gastroenterol. 1987 Oct;82(10):1057-61.
引用本文的文献
1
Elevated resistive index in the hepatic artery as a predictor of fulminant hepatic failure in patients with acute viral hepatitis: a prospective study using Doppler ultrasound.肝动脉阻力指数升高作为急性病毒性肝炎患者暴发性肝衰竭的预测指标：一项使用多普勒超声的前瞻性研究
Dig Dis Sci. 2004 May;49(5):833-42. doi: 10.1023/b:ddas.0000030096.92860.5a.
2
Portal hemodynamics in fulminant hepatic failure as assessed by duplex Doppler ultrasonography.经双功多普勒超声评估暴发性肝衰竭中的门静脉血流动力学。
Dig Dis Sci. 2001 Mar;46(3):504-8. doi: 10.1023/a:1005634812578.
3
Tolcapone-related fulminant hepatitis: electron microscopy shows mitochondrial alterations.
Dig Dis Sci. 2000 Sep;45(9):1881-4. doi: 10.1023/a:1005549304404.
4
Prognostic evaluation of early indicators in fulminant hepatic failure by multivariate analysis.通过多因素分析对暴发性肝衰竭早期指标进行预后评估。
Dig Dis Sci. 1998 Jun;43(6):1311-6. doi: 10.1023/a:1018876328561.
5
Ketoconazole-induced fulminant hepatitis.酮康唑诱发的暴发性肝炎。
Gut. 1985 Jun;26(6):636-8. doi: 10.1136/gut.26.6.636.
6
Fulminant hepatic failure in childhood.
Indian J Pediatr. 1985 Nov-Dec;52(419):587-92. doi: 10.1007/BF02749560.
7
Relationship between degree of portal hypertension and liver histologic lesions in patients with alcoholic cirrhosis. Effect of acute alcoholic hepatitis on portal hypertension.
Dig Dis Sci. 1987 Apr;32(4):337-43. doi: 10.1007/BF01296284.
8
Hemodynamics and coagulation in experimental auxiliary liver transplantation during fulminant hepatic failure.暴发性肝衰竭时实验性辅助性肝移植的血流动力学与凝血功能
Ann Surg. 1986 Nov;204(5):552-8. doi: 10.1097/00000658-198611000-00008.
9
Fatal variceal haemorrhage after paracetamol overdose.对乙酰氨基酚过量服用后发生致命性静脉曲张出血。
Gut. 1989 Oct;30(10):1424-5. doi: 10.1136/gut.30.10.1424.
10
Portal hypertension in acute liver failure.急性肝衰竭中的门静脉高压
Gut. 1992 Jul;33(7):965-8. doi: 10.1136/gut.33.7.965.
本文引用的文献
1
Portal hypertension with esophageal varices in acute infectious hepatitis: further observations.急性传染性肝炎合并门静脉高压症及食管静脉曲张：进一步观察
Am J Med Sci. 1959 May;237(5):596-9. doi: 10.1097/00000441-195905000-00007.
2
3
Arteriovenous shunting in high cardiac output shcok syndromes.
Surg Gynecol Obstet. 1968 Aug;127(2):282-8.
4
Changes in hepatic circulation at rest, during and after exercise in young males with infectious hepatitis compared with controls.
Acta Med Scand. 1974 Oct;196(4):315-25. doi: 10.1111/j.0954-6820.1974.tb01017.x.
5
Acute hepatic necrosis and fulminant hepatic failure.急性肝坏死和暴发性肝衰竭。
Gut. 1973 Oct;14(10):805-15. doi: 10.1136/gut.14.10.805.
6
Abnormalities of sodium excretion and other disorders of renal function in fulminant hepatic failure.暴发性肝衰竭时钠排泄异常及其他肾功能障碍
Gut. 1976 Jul;17(7):501-5. doi: 10.1136/gut.17.7.501.
7
Direct transhepatic measurement of portal vein pressure using a thin needle. Comparison with wedged hepatic vein pressure.使用细针经肝直接测量门静脉压力。与肝静脉楔压的比较。
Gastroenterology. 1977 Apr;72(4 Pt 1):584-9.
8
Transvenous (transjugular) liver biopsy. An experience based on 100 biopsies.经静脉（经颈静脉）肝活检。基于100例活检的经验。
Am J Dig Dis. 1978 Apr;23(4):302-4. doi: 10.1007/BF01072410.
9
Portal circulation and portal hypertension.门静脉循环与门静脉高压症。
Gut. 1978 Jan;19(1):70-83. doi: 10.1136/gut.19.1.70.
Zotero 插件