Lebrec D, Nouel O, Bernuau J, Rueff B, Benhamou J P
Gut. 1980 Nov;21(11):962-4. doi: 10.1136/gut.21.11.962.
The gradient between wedged and free hepatic venous pressures were measured in 10 unselected adult patients suffering from fulminant viral hepatitis. The gradient was increased in all the studied patients, ranging from 0.9 to 2.1 kPa; this finding indicates that portal hypertension was present in all these cases. Ascites was present in all the five patients having a gradient about 1.5 kPa and affected only two of the five patients having a gradient below 1.5 kPa; this observation suggests that portal hypertension plays a role in the mechanism of ascites in fulminant viral hepatitis. Portal hypertension in fulminant viral hepatitis is likely to be the consequence of an intrahepatic block due to massive necrosis of the liver cells.
对10例未经过挑选的暴发性病毒性肝炎成年患者测量了肝静脉楔压与自由肝静脉压之间的梯度。所有研究患者的梯度均升高，范围为0.9至2.1 kPa；这一发现表明所有这些病例均存在门静脉高压。梯度约为1.5 kPa的所有5例患者均出现腹水，而梯度低于1.5 kPa的5例患者中只有2例出现腹水；这一观察结果提示门静脉高压在暴发性病毒性肝炎腹水形成机制中起作用。暴发性病毒性肝炎中的门静脉高压很可能是肝细胞大量坏死导致肝内阻塞的结果。
