Blaser M J, Hickman F W, Farmer J J, Brenner D J, Balows A, Feldman R A
J Infect Dis. 1980 Dec;142(6):934-8. doi: 10.1093/infdis/142.6.934.
As a part of educational and proficiency exercises thousands of students and laboratory personnel have been exposed to Salmonella typhi. In a retrospective study 24 cases of laboratory-acquired typhoid fever in the United states during a 33-month period were identified; laboratory-acquired cases represented only 2.4% of all typhoid cases but 11.2% of the sporadic cases. Twenty-one of the 24 cases occurred when S. typhi was voluntarily introduced into the laboratory for educational proficiency testing or research purposes. Twelve patients were exposed to S. typhi when working with it as an unknown organism; another five were merely present in the laboratory. Obvious breaks in technique were found to be the cause of infection for only seven of the 24 patients, although infection of the others implies that breaks in technique occurred. Laboratory-acquired typhoid fever may severe as a marker for other less severe laboratory-acquired infections; these data suggest that such infections could be common.
作为教育和技能训练的一部分，数千名学生和实验室工作人员接触过伤寒沙门氏菌。在一项回顾性研究中，确定了美国在33个月期间有24例实验室获得性伤寒热病例；实验室获得性病例仅占所有伤寒病例的2.4%，但占散发病例的11.2%。24例病例中有21例是在为教育技能测试或研究目的而将伤寒沙门氏菌自愿引入实验室时发生的。12名患者在将其作为未知生物体进行操作时接触到了伤寒沙门氏菌；另外5名患者只是在实验室中。在24名患者中，仅发现7名患者的感染原因是明显的技术失误，尽管其他患者的感染意味着发生了技术失误。实验室获得性伤寒热可能严重，可作为其他不太严重的实验室获得性感染的标志；这些数据表明此类感染可能很常见。
