Anderson L J, Baer G M, Smith J S, Winkler W G, Holman R C
Am J Epidemiol. 1981 Mar;113(3):270-5. doi: 10.1093/oxfordjournals.aje.a113096.
The speed of antibody response to two administration schedules of human diploid cell strains rabies vaccine (HDCV) was measured in two groups of veterinary students as a preliminary study to the use of interferon inducers plus vaccine for rabies treatment. When four doses of HDCV were administered in three days instead of four doses in 14 days, 94.7 per cent of those injected had antibody by the seventh day, versus 31.6 per cent in the 14-day group. The maximum titer was lower and antibody fell more quickly in the group with the shorter time interval between doses. This study shows the feasibility of inducing the same rapid antibody response in humans as that noted in rhesus monkeys where the mortality from rabies virus challenge was markedly reduced after treatment with interferon inducers and HDCV.
作为使用干扰素诱导剂加狂犬病疫苗进行治疗的初步研究，在两组兽医学生中测量了对两种人二倍体细胞狂犬病疫苗（HDCV）接种方案的抗体反应速度。当在三天内接种四剂HDCV，而不是在14天内接种四剂时，7天内接种者中有94.7%产生了抗体，而14天接种组为31.6%。在剂量间隔时间较短的组中，最大滴度较低，抗体下降更快。这项研究表明，在人类中诱导出与恒河猴相同的快速抗体反应是可行的，在恒河猴中，用干扰素诱导剂和HDCV治疗后，狂犬病病毒攻击的死亡率显著降低。
