Mann J M, Martin S, Hoffman R, Marrazzo S
Am J Public Health. 1981 Mar;71(3):266-9. doi: 10.2105/ajph.71.3.266.
A large outbreak of foodborne botulism provided an opportunity to study the recovery from type A botulism in a group of 27 patients. Patients were interviewed either nine or 13 months after the outbreak, and a written questionnaire was mailed at 24 months, to obtain information on each patient's symptom complex and on subsequent symptom resolution. Recovery from symptoms of botulism was slow. Patients reported that resolution of 50 per cent of their original symptoms occurred by an average of 5 months. Thirteen of 14 patients contacted 13 months after onset of botulism reported some persistent symptoms. This study, although limited to interview data, strengthens the concept of a prolonged recovery phase in botulism, as previously suggested in individual case reports. Physicians and other health workers caring for patients with botulism should anticipate physical and psychological problems resulting from a lengthy and difficult convalescent period.
一次大规模食源性肉毒中毒事件为研究27例A型肉毒中毒患者的康复情况提供了契机。在疫情爆发后的9个月或13个月对患者进行了访谈,并在24个月时邮寄了一份书面问卷,以获取每位患者的症状复合体以及后续症状缓解的信息。肉毒中毒症状的恢复缓慢。患者报告称,平均5个月后原有症状的50%得到缓解。在肉毒中毒发病13个月后联系的14例患者中有13例报告仍有一些持续症状。本研究虽然仅限于访谈数据,但强化了肉毒中毒康复期延长的概念,正如之前个别病例报告中所指出的那样。治疗肉毒中毒患者的医生和其他医护人员应预见到漫长而艰难的康复期会导致身体和心理问题。