Evarts E V, Teräväinen H, Calne D B
Brain. 1981 Mar;104(Pt 1):167-86. doi: 10.1093/brain/104.1.167.
Both reaction time and movement time tend to be prolonged in Parkinson's disease, but they are often impaired independently of each other. Prolongation of RT is relatively slight, while MT undergoes more substantial and consistent disturbance. Choice RT and kinaesthetic RT do not have any advantage over simple visual RT as measurements of neurological deficit in parkinsonism, since they are all impaired to the same extent. MT is more useful than RT as an objective indicator of therapeutic efficacy, but further studies of RT (with tests requiring programming of displacement, velocity, and accuracy) may provide insights into the nature of the central motor disorder in Parkinson's disease.
帕金森病患者的反应时间和运动时间往往都会延长,但二者常常相互独立地受到损害。反应时间的延长相对轻微,而运动时间受到的干扰则更显著且持续。作为帕金森病神经功能缺损的测量指标,选择反应时间和动觉反应时间并不比简单视觉反应时间更具优势,因为它们受到的损害程度相同。运动时间作为治疗效果的客观指标比反应时间更有用,但对反应时间进行进一步研究(采用要求对位移、速度和准确性进行编程的测试)可能会为帕金森病中枢运动障碍的本质提供见解。