• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

γ干扰素对于抵抗泰勒氏病毒诱导的脱髓鞘至关重要。

Gamma interferon is critical for resistance to Theiler's virus-induced demyelination.

作者信息

Rodriguez M, Pavelko K, Coffman R L

机构信息

Department of Neurology, Mayo Medical School, Rochester, Minnesota 55905, USA.

出版信息

J Virol. 1995 Nov;69(11):7286-90. doi: 10.1128/JVI.69.11.7286-7290.1995.

DOI:10.1128/JVI.69.11.7286-7290.1995
PMID:7474155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189655/
Abstract

Administration of neutralizing monoclonal antibody to gamma interferon increased Theiler's virus-induced demyelination and virus antigen persistence in the spinal cord in susceptible SJL/J mice and completely abrogated resistance such that all C57BL/10SNJ mice developed demyelination. These experiments support the hypothesis that gamma interferon is critically important for resistance to Theiler's virus-induced disease but is not required for myelin destruction.

摘要

对易感的SJL/J小鼠注射γ干扰素中和单克隆抗体，会增加泰勒病毒诱导的脱髓鞘以及脊髓中病毒抗原的持续存在，并完全消除抵抗力，以至于所有C57BL/10SNJ小鼠都发生了脱髓鞘。这些实验支持了这样一种假说，即γ干扰素对于抵抗泰勒病毒诱导的疾病至关重要，但对于髓鞘破坏并非必需。

相似文献

1
Gamma interferon is critical for resistance to Theiler's virus-induced demyelination.γ干扰素对于抵抗泰勒氏病毒诱导的脱髓鞘至关重要。
J Virol. 1995 Nov;69(11):7286-90. doi: 10.1128/JVI.69.11.7286-7290.1995.
2
Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection.在早期颅内感染泰勒氏鼠脑脊髓炎病毒后，γ干扰素对于一种易感小鼠品系的神经元病毒清除和保护至关重要。
J Virol. 2003 Nov;77(22):12252-65. doi: 10.1128/jvi.77.22.12252-12265.2003.
3
A hybrid between a resistant and a susceptible strain of mouse alters the pattern of Theiler's murine encephalomyelitis virus-induced white matter disease and favors oligodendrocyte-mediated remyelination.抗性小鼠品系和易感小鼠品系之间的杂交改变了泰勒氏鼠脑脊髓炎病毒诱导的白质疾病模式，并有利于少突胶质细胞介导的髓鞘再生。
Mult Scler. 1995 Jun;1(2):95-103. doi: 10.1177/135245859500100207.
4
Spontaneous CNS remyelination in beta 2 microglobulin-deficient mice following virus-induced demyelination.β2微球蛋白缺陷小鼠在病毒诱导脱髓鞘后中枢神经系统的自发再髓鞘化
J Neurosci. 1995 Dec;15(12):8345-52. doi: 10.1523/JNEUROSCI.15-12-08345.1995.
5
5-Fluorouracil and levamisole exacerbate demyelination in susceptible mice infected with Theiler's virus.5-氟尿嘧啶和左旋咪唑会加剧感染泰勒病毒的易感小鼠的脱髓鞘病变。
Exp Neurol. 1997 Sep;147(1):123-9. doi: 10.1006/exnr.1997.6598.
6
Investigation of the role of delayed-type-hypersensitivity responses to myelin in the pathogenesis of Theiler's virus-induced demyelinating disease.迟发型超敏反应对髓鞘的反应在泰勒病毒诱导的脱髓鞘疾病发病机制中的作用研究。
Immunology. 1998 Apr;93(4):478-84. doi: 10.1046/j.1365-2567.1998.00459.x.
7
Infection of class II-deficient mice by the DA strain of Theiler's virus.用泰勒氏病毒DA株感染II类缺陷小鼠。
J Virol. 1996 Jul;70(7):4811-5. doi: 10.1128/JVI.70.7.4811-4815.1996.
8
The role of CD4+ and CD8+ T cells in demyelinating disease following Theiler's virus infection: a model for multiple sclerosis.CD4+和CD8+ T细胞在泰勒氏病毒感染后脱髓鞘疾病中的作用：多发性硬化症模型
J Neurovirol. 1997 May;3 Suppl 1:S43-5.
9
Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors.对缺乏α/β干扰素受体或γ干扰素受体的129Sv小鼠进行泰勒氏病毒感染。
J Exp Med. 1995 Jun 1;181(6):2069-76. doi: 10.1084/jem.181.6.2069.
10
The TIM-3 pathway ameliorates Theiler's murine encephalomyelitis virus-induced demyelinating disease.TIM-3通路可改善泰勒氏鼠脑脊髓炎病毒诱导的脱髓鞘疾病。
Int Immunol. 2014 Jul;26(7):369-81. doi: 10.1093/intimm/dxt056. Epub 2014 Jan 31.

引用本文的文献

1
Contribution of microglia/macrophage to the pathogenesis of TMEV infection in the central nervous system.小胶质细胞/巨噬细胞对中枢神经系统中TMEV感染发病机制的作用。
Front Microbiol. 2024 Aug 2;15:1452390. doi: 10.3389/fmicb.2024.1452390. eCollection 2024.
2
Critical role of TLR activation in viral replication, persistence, and pathogenicity of Theiler's virus.TLR 激活在 Theiler 病毒的复制、持续存在和致病性方面起着关键作用。
Front Immunol. 2023 Apr 20;14:1167972. doi: 10.3389/fimmu.2023.1167972. eCollection 2023.
3
IFN-β Deficiency Results in Fatal or Demyelinating Disease in C57BL/6 Mice Infected With Theiler's Murine Encephalomyelitis Viruses.IFN-β 缺陷导致感染 Theiler 氏鼠脑脊髓炎病毒的 C57BL/6 小鼠发生致死性或脱髓鞘疾病。
Front Immunol. 2022 Feb 9;13:786940. doi: 10.3389/fimmu.2022.786940. eCollection 2022.
4
Excessive Innate Immunity Steers Pathogenic Adaptive Immunity in the Development of Theiler's Virus-Induced Demyelinating Disease.过度的先天免疫在泰勒病毒诱导的脱髓鞘疾病发展过程中引导致病性适应性免疫。
Int J Mol Sci. 2021 May 17;22(10):5254. doi: 10.3390/ijms22105254.
5
Direct Antiviral Mechanisms of Interferon-Gamma.γ-干扰素的直接抗病毒机制
Immune Netw. 2018 Oct 17;18(5):e33. doi: 10.4110/in.2018.18.e33. eCollection 2018 Oct.
6
Cytokine Signaling in Multiple Sclerosis and Its Therapeutic Applications.细胞因子信号传导在多发性硬化症中的作用及其治疗应用
Med Sci (Basel). 2017 Oct 13;5(4):23. doi: 10.3390/medsci5040023.
7
Host genetic background influences diverse neurological responses to viral infection in mice.宿主遗传背景影响小鼠对病毒感染的多种神经反应。
Sci Rep. 2017 Sep 22;7(1):12194. doi: 10.1038/s41598-017-12477-2.
8
Theiler's murine encephalomyelitis virus infection of SJL/J and C57BL/6J mice: Models for multiple sclerosis and epilepsy.泰勒氏鼠脑脊髓炎病毒感染SJL/J和C57BL/6J小鼠：多发性硬化症和癫痫的模型
J Neuroimmunol. 2017 Jul 15;308:30-42. doi: 10.1016/j.jneuroim.2017.02.012. Epub 2017 Feb 12.
9
Human class I major histocompatibility complex alleles determine central nervous system injury versus repair.人类I类主要组织相容性复合体等位基因决定中枢神经系统损伤与修复。
J Neuroinflammation. 2016 Nov 17;13(1):293. doi: 10.1186/s12974-016-0759-4.
10
Preferential induction of protective T cell responses to Theiler's virus in resistant (C57BL/6 x SJL)F1 mice.优先诱导抵抗（C57BL/6 x SJL）F1 小鼠对 Theiler 病毒的保护性 T 细胞反应。
J Virol. 2011 Mar;85(6):3033-40. doi: 10.1128/JVI.02400-10. Epub 2010 Dec 29.

本文引用的文献

1
Split tolerance of Th1 and Th2 cells in tolerance to Theiler's murine encephalomyelitis virus.在对泰勒氏鼠脑脊髓炎病毒的耐受性中Th1和Th2细胞的分裂耐受性。
Eur J Immunol. 1993 Jan;23(1):46-55. doi: 10.1002/eji.1830230109.
2
Theiler's virus infection of beta 2-microglobulin-deficient mice.β2-微球蛋白缺陷小鼠的泰勒氏病毒感染
J Virol. 1993 Jan;67(1):589-92. doi: 10.1128/JVI.67.1.589-592.1993.
3
Class I-deficient resistant mice intracerebrally inoculated with Theiler's virus show an increased T cell response to viral antigens and susceptibility to demyelination.用泰勒氏病毒脑内接种I类缺陷抗性小鼠，可显示出对病毒抗原的T细胞反应增强以及对脱髓鞘的易感性增加。
Eur J Immunol. 1993 Sep;23(9):2287-93. doi: 10.1002/eji.1830230935.
4
Abrogation of resistance to Theiler's virus-induced demyelination in H-2b mice deficient in beta 2-microglobulin.在缺乏β2-微球蛋白的H-2b小鼠中，对泰勒氏病毒诱导的脱髓鞘的抗性消除。
J Immunol. 1993 Jul 1;151(1):266-76.
5
Endogenous gamma interferon produced in central nervous system by systemic infection with Theiler's virus in mice.小鼠感染泰勒病毒后，中枢神经系统产生内源性γ干扰素。
J Neuroimmunol. 1993 Nov-Dec;48(2):205-11. doi: 10.1016/0165-5728(93)90193-3.
6
Mapping loci influencing the persistence of Theiler's virus in the murine central nervous system.定位影响泰勒氏病毒在小鼠中枢神经系统中持续存在的基因座。
Nat Genet. 1993 Sep;5(1):87-91. doi: 10.1038/ng0993-87.
7
Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis.重组人白细胞介素-6在多发性硬化症病毒模型中抑制脱髓鞘。
J Immunol. 1994 Oct 15;153(8):3811-21.
8
Alteration in the level of interferon-gamma results in acceleration of Theiler's virus-induced demyelinating disease.γ-干扰素水平的改变会导致泰勒氏病毒诱导的脱髓鞘疾病加速发展。
J Neuroimmunol. 1994 Dec;55(2):143-52. doi: 10.1016/0165-5728(94)90004-3.
9
Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors.对缺乏α/β干扰素受体或γ干扰素受体的129Sv小鼠进行泰勒氏病毒感染。
J Exp Med. 1995 Jun 1;181(6):2069-76. doi: 10.1084/jem.181.6.2069.
10
Neonatal infection with the Daniels strain of Theiler's murine encephalomyelitis virus.新生小鼠感染泰勒氏鼠脑脊髓炎病毒丹尼尔斯株。
Lab Invest. 1983 Dec;49(6):672-9.