γ干扰素对于抵抗泰勒氏病毒诱导的脱髓鞘至关重要。
Gamma interferon is critical for resistance to Theiler's virus-induced demyelination.
作者信息
Rodriguez M, Pavelko K, Coffman R L
机构信息
Department of Neurology, Mayo Medical School, Rochester, Minnesota 55905, USA.
出版信息
J Virol. 1995 Nov;69(11):7286-90. doi: 10.1128/JVI.69.11.7286-7290.1995.
Abstract
Administration of neutralizing monoclonal antibody to gamma interferon increased Theiler's virus-induced demyelination and virus antigen persistence in the spinal cord in susceptible SJL/J mice and completely abrogated resistance such that all C57BL/10SNJ mice developed demyelination. These experiments support the hypothesis that gamma interferon is critically important for resistance to Theiler's virus-induced disease but is not required for myelin destruction.
摘要
对易感的SJL/J小鼠注射γ干扰素中和单克隆抗体，会增加泰勒病毒诱导的脱髓鞘以及脊髓中病毒抗原的持续存在，并完全消除抵抗力，以至于所有C57BL/10SNJ小鼠都发生了脱髓鞘。这些实验支持了这样一种假说，即γ干扰素对于抵抗泰勒病毒诱导的疾病至关重要，但对于髓鞘破坏并非必需。
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本文引用的文献
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Class I-deficient resistant mice intracerebrally inoculated with Theiler's virus show an increased T cell response to viral antigens and susceptibility to demyelination.用泰勒氏病毒脑内接种I类缺陷抗性小鼠，可显示出对病毒抗原的T细胞反应增强以及对脱髓鞘的易感性增加。
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