Neriishi K, Akiba S, Amano T, Ogino T, Kodama K
Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan.
Radiat Res. 1995 Nov;144(2):215-21.
On the basis of previous studies showing an association between hepatitis B surface antigen (HBsAg) positivity and radiation exposure in atomic bomb (A-bomb) survivors, we investigated further the active state of hepatitis B virus (HBV) infection by incorporating tests for hepatitis B e antigen (HBeAg) and hepatitis B e antibody (anti-HBe) and HBsAg subtypes into our biennial health examinations. Among 6548 A-bomb survivors for whom HBsAg was assayed between July 1979 and July 1981, 129 persons were HBsAg positive. HBeAg and anti-HBe were measured in 104 of these persons and subtypes of HBsAg in 98 persons. Among those exposed to radiation (average liver dose 0.58 Sv), the odds ratio of HBsAg positivity tended to increase with radiation dose (P for trend = 0.024). The P values for association between the prevalence of HB e antigen and radiation dose and between the prevalence of anti-HBe and radiation dose were 0.094 and 0.17, respectively. The HB antigen subtype adr was predominant over other subtypes in both Hiroshima and Nagasaki, but the distribution of subtypes did not seem to differ in relation to radiation dose. These results suggested that A-bomb survivors remain in an active state of HBV infection and that the mechanism(s) of seroconversion may be impaired.
基于之前的研究表明原子弹（A 弹）幸存者中乙肝表面抗原（HBsAg）阳性与辐射暴露之间存在关联，我们通过在每两年一次的健康检查中加入乙肝 e 抗原（HBeAg）、乙肝 e 抗体（抗 - HBe）检测以及 HBsAg 亚型检测，进一步调查了乙肝病毒（HBV）感染的活跃状态。在 1979 年 7 月至 1981 年 7 月期间接受 HBsAg 检测的 6548 名 A 弹幸存者中，有 129 人 HBsAg 呈阳性。其中 104 人检测了 HBeAg 和抗 - HBe，98 人检测了 HBsAg 亚型。在那些受到辐射的人群中（平均肝脏剂量 0.58 Sv），HBsAg 阳性的优势比倾向于随辐射剂量增加（趋势 P 值 = 0.024）。HBe 抗原流行率与辐射剂量之间以及抗 - HBe 流行率与辐射剂量之间的关联 P 值分别为 0.094 和 0.17。在广岛和长崎，HB 抗原亚型 adr 比其他亚型更占主导地位，但亚型分布似乎与辐射剂量无关。这些结果表明 A 弹幸存者仍处于 HBV 感染的活跃状态，并且血清转换机制可能受损。
