青霉素治疗的时机影响肺炎链球菌引起的中耳炎症病程。
Timing of penicillin treatment influences the course of Streptococcus pneumoniae-induced middle ear inflammation.
作者信息
Sato K, Quartey M K, Liebeler C L, Giebink G S
机构信息
Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, USA.
出版信息
Antimicrob Agents Chemother. 1995 Aug;39(8):1896-8. doi: 10.1128/AAC.39.8.1896.
Abstract
Penicillin treatment timing, using the chinchilla pneumococcal otitis media model, was investigated. Early treatment (when approximately 10(3) pneumococcal CFU/ml was present in middle ear fluid) significantly accelerated inflammatory-cell influx, whereas late treatment (with approximately 10(7) pneumococcal CFU/ml present in middle ear fluid) did not. Therefore, antiinflammatory interventions will be needed early in the course of inflammation.
摘要
利用豚鼠肺炎球菌性中耳炎模型，对青霉素治疗时机进行了研究。早期治疗（当中耳液中存在约10³ 肺炎球菌CFU/ml时）显著加速了炎症细胞的流入，而晚期治疗（当中耳液中存在约10⁷ 肺炎球菌CFU/ml时）则没有。因此，在炎症过程早期将需要抗炎干预措施。
相似文献
1
Timing of penicillin treatment influences the course of Streptococcus pneumoniae-induced middle ear inflammation.青霉素治疗的时机影响肺炎链球菌引起的中耳炎症病程。
Antimicrob Agents Chemother. 1995 Aug;39(8):1896-8. doi: 10.1128/AAC.39.8.1896.
2
Optimal dose of amoxicillin in treatment of otitis media caused by a penicillin-resistant pneumococcus strain in the gerbil model.在沙鼠模型中，阿莫西林治疗由青霉素耐药肺炎球菌菌株引起的中耳炎的最佳剂量。
Antimicrob Agents Chemother. 2002 Mar;46(3):859-62. doi: 10.1128/AAC.46.3.859-862.2002.
3
Penicillin treatment accelerates middle ear inflammation in experimental pneumococcal otitis media.青霉素治疗会加速实验性肺炎球菌性中耳炎的中耳炎症。
Infect Immun. 1992 May;60(5):1908-12. doi: 10.1128/iai.60.5.1908-1912.1992.
4
Surface Proteins and Pneumolysin of Encapsulated and Nonencapsulated Streptococcus pneumoniae Mediate Virulence in a Chinchilla Model of Otitis Media.包膜和非包膜肺炎链球菌的表面蛋白及肺炎溶血素在栗鼠中耳炎模型中介导毒力
Front Cell Infect Microbiol. 2016 May 18;6:55. doi: 10.3389/fcimb.2016.00055. eCollection 2016.
5
Experimental otitis media following middle ear inoculation of nonviable Streptococcus pneumoniae.
Ann Otol Rhinol Laryngol. 1980 Sep-Oct;89(5 Pt 1):479-82. doi: 10.1177/000348948008900523.
6
Efficacy of linezolid in experimental otitis media.利奈唑胺在实验性中耳炎中的疗效。
Antimicrob Agents Chemother. 2000 Mar;44(3):654-7. doi: 10.1128/AAC.44.3.654-657.2000.
7
Effect of apolactoferrin on experimental pneumococcal otitis media.脱铁乳铁蛋白对实验性肺炎球菌性中耳炎的作用。
Arch Otolaryngol Head Neck Surg. 2010 Nov;136(11):1127-31. doi: 10.1001/archoto.2010.192.
8
Replication of type 5 adenovirus promotes middle ear infection by Streptococcus pneumoniae in the chinchilla model of otitis media.在栗鼠中耳炎模型中，5型腺病毒的复制会促进肺炎链球菌引发的中耳感染。
Pathog Dis. 2015 Mar;73(2):1-8. doi: 10.1111/2049-632X.12216. Epub 2015 Feb 26.
9
Effect of antibiotic treatment delay on therapeutic outcome of experimental acute otitis media caused by Streptococcus pneumoniae strains with different susceptibilities to amoxicillin.抗生素治疗延迟对不同阿莫西林敏感性肺炎链球菌所致实验性急性中耳炎治疗结果的影响
Antimicrob Agents Chemother. 2004 Mar;48(3):860-6. doi: 10.1128/AAC.48.3.860-866.2004.
10
Effect of penicillin on experimental acute otitis media. A histopathological study of goblet cell density, bone modelling dynamics, polyp and adhesion formation.青霉素对实验性急性中耳炎的影响。杯状细胞密度、骨重塑动力学、息肉及粘连形成的组织病理学研究。
Acta Otolaryngol Suppl. 2000;543:56-7. doi: 10.1080/000164800453964-1.
引用本文的文献
1
Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect.评估阿莫西林在龙猫中耳液中的流入/流出情况并同步测量抗菌效果。
Antimicrob Agents Chemother. 2007 Dec;51(12):4336-41. doi: 10.1128/AAC.00405-07. Epub 2007 Oct 8.
2
Bacterial endophthalmitis: epidemiology, therapeutics, and bacterium-host interactions.细菌性眼内炎：流行病学、治疗方法及细菌与宿主的相互作用
Clin Microbiol Rev. 2002 Jan;15(1):111-24. doi: 10.1128/CMR.15.1.111-124.2002.
3
Middle ear fluid cytokine and inflammatory cell kinetics in the chinchilla otitis media model.灰鼠中耳炎模型中中耳积液细胞因子及炎症细胞动力学
Infect Immun. 1999 Apr;67(4):1943-6. doi: 10.1128/IAI.67.4.1943-1946.1999.
4
Development of experimental pneumonia by infection with penicillin-insensitive Streptococcus pneumoniae in guinea pigs and their treatment with amoxicillin, cefotaxime, and meropenem.豚鼠感染对青霉素不敏感的肺炎链球菌导致实验性肺炎的发生以及用阿莫西林、头孢噻肟和美罗培南对其进行治疗
Antimicrob Agents Chemother. 1996 Dec;40(12):2698-702. doi: 10.1128/AAC.40.12.2698.
5
Roles of autolysin and pneumolysin in middle ear inflammation caused by a type 3 Streptococcus pneumoniae strain in the chinchilla otitis media model.自溶素和肺炎溶血素在栗鼠中耳炎模型中由3型肺炎链球菌菌株引起的中耳炎症中的作用。
Infect Immun. 1996 Apr;64(4):1140-5. doi: 10.1128/iai.64.4.1140-1145.1996.
本文引用的文献
1
Detection of pneumococcal capsular antigen in the presence of penicillin in vitro.体外在青霉素存在的情况下检测肺炎球菌荚膜抗原。
Scand J Infect Dis. 1993;25(3):317-22. doi: 10.3109/00365549309008505.
2
Detection of Pneumococcal Capsular polysaccharide antigens by latex agglutination, counterimmunoelectrophoresis, and radioimmunoassay in middle ear exudates in acute otitis media.通过乳胶凝集试验、对流免疫电泳和放射免疫测定法检测急性中耳炎中耳渗出液中的肺炎球菌荚膜多糖抗原。
J Clin Microbiol. 1980 Feb;11(2):135-40. doi: 10.1128/jcm.11.2.135-140.1980.
3
The bacteriology and cytology of chronic otitis media with effusion.分泌性中耳炎的细菌学和细胞学
Pediatr Infect Dis. 1982 Mar-Apr;1(2):98-103. doi: 10.1097/00006454-198203000-00007.
4
Animal models for studying pneumococcal otitis media and pneumococcal vaccine efficacy.用于研究肺炎球菌性中耳炎及肺炎球菌疫苗效力的动物模型。
Ann Otol Rhinol Laryngol Suppl. 1980 May-Jun;89(3 Pt 2):339-43. doi: 10.1177/00034894800890s380.
5
The induction of meningeal inflammation by components of the pneumococcal cell wall.肺炎球菌细胞壁成分诱导脑膜炎症
J Infect Dis. 1985 May;151(5):859-68. doi: 10.1093/infdis/151.5.859.
6
The relative role of bacterial cell wall and capsule in the induction of inflammation in pneumococcal meningitis.细菌细胞壁和荚膜在肺炎球菌性脑膜炎炎症诱导中的相对作用。
J Infect Dis. 1985 Mar;151(3):535-40. doi: 10.1093/infdis/151.3.535.
7
Nonsteroidal anti-inflammatory agents in the therapy for experimental pneumococcal meningitis.非甾体抗炎药在实验性肺炎球菌性脑膜炎治疗中的应用
J Infect Dis. 1987 May;155(5):985-90. doi: 10.1093/infdis/155.5.985.
8
The contribution of pneumococcal cell wall to the pathogenesis of experimental otitis media.肺炎球菌细胞壁在实验性中耳炎发病机制中的作用。
J Infect Dis. 1988 Feb;157(2):245-55. doi: 10.1093/infdis/157.2.245.
9
Experimental animal models for studying antimicrobial pharmacokinetics in otitis media.
Pharm Res. 1989 Apr;6(4):279-85. doi: 10.1023/a:1015938205892.
10
Influence of antibiotic dose, dosing interval, and duration of therapy on outcome in experimental pneumococcal meningitis in rabbits.抗生素剂量、给药间隔及治疗持续时间对兔实验性肺炎球菌性脑膜炎预后的影响。
Antimicrob Agents Chemother. 1989 Apr;33(4):418-23. doi: 10.1128/AAC.33.4.418.
Zotero 插件