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[瓣周脓肿:关于59例病例的多中心研究]

[Valve ring abscesses: apropos of 59 cases. A multicenter study].

作者信息

Lesbre J P, Tribouilloy C, Jaubourg M L, Roudaut R, Wolf J, Eicher J C, Denis B, Hadjian O, Lusson J R, Justin E P

机构信息

Département de cardiologie, CHRU d'Amiens, Salouël.

出版信息

Arch Mal Coeur Vaiss. 1995 Mar;88(3):321-8.

PMID:7487285
Abstract

The authors report the results of a multicenter study which recensed 59 cases (46 men, 13 women, average age 59.8 +/- 14 years) of valve ring abscesses defined by echocardiographic criteria alone (20 cases) or by echocardiographic and/or operative criteria (39 cases). The site of abscess was aortic (53 cases), mitral (5 cases) and tricuspid (1 case). The abscess complicated a prosthetic valve in 34 cases, occurred with a non-pathological valve in 11 cases or a pathological valve in 14 cases. Taking the 39 operated patients as a reference, the diagnostic sensitivity of transthoracic echocardiography was 25% and that of transoesophageal echocardiography: 88%. Bacterial vegetations were diagnosed with a sensitivity of 55% for transthoracic and 88% for transoesophageal echocardiography. The mediocre results of transthoracic echocardiography make transoesophageal echocardiography mandatory when there is a clinical suspicion of abscess: transoesophageal echocardiography should be systematic in prosthetic valve endocarditis and widely employed in native aortic valve endocarditis. The clinical outcome of these cases was: 39 cases were operated: global mortality of 23%, and 18 cases were treated medically, surgery having been declined for various reasons: old age (2 patients), operative risk (1 patient), patient refusal (4 patients), general condition considered to be too good to justify surgery (11 cases, including 6 sterilised abscesses diagnosed some time after the acute infectious phase). The outcome of these 18 patients, who form the biggest non-operated series of valve ring abscesses to date, was studied in detail: 4 died (18% mortality), 1 was operated secondarily for progressive valve dehiscence and 13 had a favourable outcome with an average follow-up period of 2 years.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

作者报告了一项多中心研究的结果,该研究收纳了59例瓣膜环脓肿病例(46例男性,13例女性,平均年龄59.8±14岁),这些病例仅通过超声心动图标准确诊(20例),或通过超声心动图和/或手术标准确诊(39例)。脓肿部位为主动脉瓣(53例)、二尖瓣(5例)和三尖瓣(1例)。34例脓肿并发人工瓣膜,11例发生于非病理性瓣膜,14例发生于病理性瓣膜。以39例接受手术的患者为参照,经胸超声心动图的诊断敏感性为25%,经食管超声心动图的诊断敏感性为88%。经胸超声心动图诊断细菌性赘生物的敏感性为55%,经食管超声心动图为88%。经胸超声心动图结果欠佳,因此当临床怀疑有脓肿时,经食管超声心动图检查必不可少:在人工瓣膜心内膜炎中应常规进行经食管超声心动图检查,在天然主动脉瓣心内膜炎中应广泛应用。这些病例的临床结局如下:39例接受手术,总体死亡率为23%;18例接受药物治疗,因各种原因未进行手术:高龄(2例)、手术风险(1例)、患者拒绝(4例)、一般状况被认为良好无需手术(11例,包括6例在急性感染期后一段时间诊断为已治愈的脓肿)。对这18例患者(构成了迄今为止最大的未手术瓣膜环脓肿系列)的结局进行了详细研究:4例死亡(死亡率18%),1例因瓣膜逐渐裂开而二次手术,13例预后良好,平均随访期为2年。(摘要截选至250词)

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