Blazeby J M, Williams M H, Brookes S T, Alderson D, Farndon J R
University Department of Surgery, Bristol Royal Infirmary.
Gut. 1995 Oct;37(4):505-8. doi: 10.1136/gut.37.4.505.
Quality of life (QOL) measurement may aid decision making in the treatment of patients with oesophageal cancer but must be clinically valid to be useful. This study considered if the European Organisation for Research and Treatment of Cancer QOL questionnaire, the QLQ-C30, showed differing results in two clinically distinct groups of patients with oesophageal cancer and also investigated the correlation between dysphagia grade and various scales of QOL. Patients treated by oesophagectomy reported significantly better physical, emotional, cognitive, and global health scores than those in the palliative treatment group. Patients who received palliative treatment had significantly worse pain, fatigue, appetite loss, constipation, and dysphagia. The correlations between dysphagia grade and each of the QOL scales and items in both groups of patients were poor. This questionnaire differentiates clearly between the two clinically distinct groups of patients, but to be an entirely appropriate indicator of QOL in patients with oesophageal cancer, an additional specific oesophageal module including a dysphagia scale is required.
生活质量（QOL）测量可能有助于食管癌患者治疗中的决策制定，但必须具有临床有效性才有用。本研究探讨了欧洲癌症研究与治疗组织的生活质量问卷QLQ-C30在两组临床特征不同的食管癌患者中是否显示出不同结果，同时还研究了吞咽困难分级与各种生活质量量表之间的相关性。接受食管切除术治疗的患者在身体、情感、认知和总体健康评分方面显著优于姑息治疗组的患者。接受姑息治疗的患者在疼痛、疲劳、食欲减退、便秘和吞咽困难方面明显更严重。两组患者中吞咽困难分级与各生活质量量表及项目之间的相关性均较差。该问卷能明确区分这两组临床特征不同的患者，但要成为食管癌患者生活质量的完全合适指标，还需要一个额外的包括吞咽困难量表的特定食管模块。
