使用猪小肠黏膜下层移植物促进大鼠逼尿肌再生：功能性神经支配和受体表达
Detrusor regeneration in the rat using porcine small intestinal submucosal grafts: functional innervation and receptor expression.
作者信息
Vaught J D, Kropp B P, Sawyer B D, Rippy M K, Badylak S F, Shannon H E, Thor K B
机构信息
Department of Urology, Indiana University School of Medicine, Indianapolis, USA.
出版信息
J Urol. 1996 Jan;155(1):374-8.
PURPOSE
To evaluate functional characteristics of regenerated bladder induced by small intestinal submucosa (SIS).
MATERIALS AND METHODS
Strips from bladder regenerated from SIS and normal rat bladder were evaluated by in vitro muscle bath contractility studies.
RESULTS
The present results indicate that SIS-regenerated bladder 1) demonstrates contractile activity; 2) expresses muscarinic, purinergic and beta adrenergic receptors; and 3) exhibits functional cholinergic and purinergic innervation that is similar to the normal rat urinary bladder muscle.
CONCLUSIONS
These functional characteristics of SIS-regenerated tissue demonstrated in the present study further support use of SIS material as a bladder augmentation material.
目的
评估小肠黏膜下层（SIS）诱导再生膀胱的功能特性。
材料与方法
通过体外肌肉浴收缩性研究评估SIS再生膀胱和正常大鼠膀胱的组织条。
结果
目前的结果表明，SIS再生膀胱1）表现出收缩活性；2）表达毒蕈碱、嘌呤能和β肾上腺素能受体；3）呈现出与正常大鼠膀胱肌肉相似的功能性胆碱能和嘌呤能神经支配。
结论
本研究中所展示的SIS再生组织的这些功能特性进一步支持将SIS材料用作膀胱扩大材料。
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