近期感染1型人类免疫缺陷病毒的女性生殖器分泌物和外周血中病毒群体的多样性。
Diversity in virus populations from genital secretions and peripheral blood from women recently infected with human immunodeficiency virus type 1.
作者信息
Poss M, Martin H L, Kreiss J K, Granville L, Chohan B, Nyange P, Mandaliya K, Overbaugh J
机构信息
Department of Microbiology, University of Washington, Seattle 98195, USA.
出版信息
J Virol. 1995 Dec;69(12):8118-22. doi: 10.1128/JVI.69.12.8118-8122.1995.
Abstract
In order to develop a human immunodeficiency virus type 1 vaccine with global efficacy, it is important to evaluate the virus populations that are transmitted to individuals living in high-incidence areas. To determine the nature of the human immunodeficiency virus type 1 population transmitted to women during heterosexual contact, we examined the diversity of the proviral envelope gene in infected cells in both genital secretions and peripheral blood from six recently seroconverted Kenyan women. Heterogeneous virus populations were present in cervical secretions and/or peripheral blood shortly after seroconversion for five of six infected individuals, and tissue-specific variants were identified in several cases.
摘要
为开发具有全球效力的1型人类免疫缺陷病毒疫苗，评估传播到高发病率地区人群的病毒群体非常重要。为确定异性接触期间传播给女性的1型人类免疫缺陷病毒群体的性质，我们检测了6名近期血清转化的肯尼亚女性的生殖分泌物和外周血中受感染细胞前病毒包膜基因的多样性。在6名受感染个体中的5名血清转化后不久，宫颈分泌物和/或外周血中存在异质病毒群体，并且在一些病例中鉴定出组织特异性变体。
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