Tary-Lehmann M, Saxon A, Lehmann P V
Dept of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-4943, USA.
Immunol Today. 1995 Nov;16(11):529-33. doi: 10.1016/0167-5699(95)80046-8.
Severe combined immunodeficiency (SCID) mice can be stably grafted with human peripheral blood lymphocytes, creating hu-PBL-SCID chimeras; essentially, these are mice with a human immune system. Here, Magdalena Tary-Lehmann, Andrew Saxon and Paul Lehmann discuss the immunobiology of these chimeras. The authors propose that hu-PBL-SCID chimerism evolves in two phases. During the first three weeks after grafting, many of the injected cells survive and the human immune system is functional. Subsequently, anti-mouse-reactive clones are selected and the immune system becomes nonfunctional. The implications of this scenario for the utilization of the hu-PBL-SCID model are discussed.
严重联合免疫缺陷（SCID）小鼠能够稳定地移植人外周血淋巴细胞，从而产生人外周血淋巴细胞 - SCID嵌合体；从本质上讲，这些是具有人类免疫系统的小鼠。在此，玛格达莱娜·塔里 - 莱曼、安德鲁·萨克森和保罗·莱曼讨论了这些嵌合体的免疫生物学。作者提出，人外周血淋巴细胞 - SCID嵌合现象分两个阶段演变。在移植后的前三周，许多注入的细胞存活下来，人类免疫系统开始发挥功能。随后，抗小鼠反应性克隆被筛选出来，免疫系统变得失去功能。文中还讨论了这种情况对人外周血淋巴细胞 - SCID模型应用的影响。
