• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

艾滋病相关恶病质状态下循环白细胞介素-1β、肿瘤坏死因子α和白细胞介素-6的差异升高

Differential elevation of circulating interleukin-1 beta, tumor necrosis factor alpha, and interleukin-6 in AIDS-associated cachectic states.

作者信息

Bélec L, Meillet D, Hernvann A, Grésenguet G, Gherardi R

机构信息

Service de Microbiologie (Virologie), Hôpital Broussais, Paris, France.

出版信息

Clin Diagn Lab Immunol. 1994 Jan;1(1):117-20. doi: 10.1128/cdli.1.1.117-120.1994.

DOI:10.1128/cdli.1.1.117-120.1994
PMID:7496913
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC368208/
Abstract

Elevation of serum interleukin-1 beta (IL-1 beta) levels, and to a lesser degree tumor necrosis factor alpha levels, was found in cachectic human immunodeficiency virus (HIV)-infected African patients without concurrent opportunistic infection or neoplasia (HIV wasting syndrome). A heterogeneous pattern of elevations of cytokine levels, including mild elevations of IL-1 beta and pronounced elevations of IL-6 levels, was found in other cachectic states.

摘要

在患有恶病质的、未并发机会性感染或肿瘤形成的非洲人类免疫缺陷病毒（HIV）感染患者（HIV消瘦综合征）中，发现血清白细胞介素-1β（IL-1β）水平升高，肿瘤坏死因子α水平也有一定程度升高。在其他恶病质状态中，发现细胞因子水平呈异质性升高模式，包括IL-1β轻度升高和IL-6显著升高。

相似文献

1
Differential elevation of circulating interleukin-1 beta, tumor necrosis factor alpha, and interleukin-6 in AIDS-associated cachectic states.艾滋病相关恶病质状态下循环白细胞介素-1β、肿瘤坏死因子α和白细胞介素-6的差异升高
Clin Diagn Lab Immunol. 1994 Jan;1(1):117-20. doi: 10.1128/cdli.1.1.117-120.1994.
2
[Overproduction of tumor necrosis factor-alpha in African patients with HIV-1 infection, cachexia and low tri-iodothyronine syndrome].
Med Trop (Mars). 1997;57(4):349-52.
3
Proinflammatory and regulatory cytokine levels in AIDS cachexia.艾滋病恶病质中促炎和调节性细胞因子水平
In Vivo. 1999 Nov-Dec;13(6):499-502.
4
Serum tumor necrosis factor alpha, interleukin 1-beta, p24 antigen concentrations and CD4+ cells at various stages of human immunodeficiency virus 1 infection in children.
Pediatr Infect Dis J. 1991 Jun;10(6):450-5. doi: 10.1097/00006454-199106000-00007.
5
Circulating interferon-alpha levels and hypertriglyceridemia in the acquired immunodeficiency syndrome.
Am J Med. 1991 Feb;90(2):154-62.
6
Elevation of cytokine levels in cachectic patients with prostate carcinoma.前列腺癌恶病质患者细胞因子水平升高。
Cancer. 2003 Mar 1;97(5):1211-6. doi: 10.1002/cncr.11178.
7
Increased tumor necrosis factor-alpha serum levels in patients with HIV wasting syndrome and euthyroid sick syndrome.HIV消瘦综合征和正常甲状腺病态综合征患者血清肿瘤坏死因子-α水平升高。
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):212-4. doi: 10.1097/00042560-199502000-00015.
8
[Cytokines in experimental cancer cachexia].[实验性癌症恶病质中的细胞因子]
Zhonghua Zhong Liu Za Zhi. 2001 Sep;23(5):382-4.
9
Inflammatory cytokines and inhibitors in HIV infection: correlation between interleukin-1 receptor antagonist and weight loss.
AIDS. 1996 Oct;10(12):1349-56. doi: 10.1097/00002030-199610000-00006.
10
Differential expression of tumor necrosis factor alpha and interleukin 1 beta compared with interleukin 6 in monocytes from human immunodeficiency virus-positive individuals measured by polymerase chain reaction.通过聚合酶链反应测定人类免疫缺陷病毒阳性个体单核细胞中肿瘤坏死因子α和白细胞介素1β与白细胞介素6的差异表达。
J Acquir Immune Defic Syndr (1988). 1994 Feb;7(2):109-15.

引用本文的文献

1
Drug-disease interaction: Clinical consequences of inflammation on drugs action and disposition.药物-疾病相互作用：炎症对药物作用和处置的临床影响。
J Pharm Pharm Sci. 2023 Feb 6;26:11137. doi: 10.3389/jpps.2023.11137. eCollection 2023.
2
Preliminary Evidence for a Relationship between Elevated Plasma TNFα and Smaller Subcortical White Matter Volume in HCV Infection Irrespective of HIV or AUD Comorbidity.初步证据表明，HCV 感染患者的血浆 TNFα 水平升高与较小的皮质下白质体积有关，而与 HIV 或 AUD 合并症无关。
Int J Mol Sci. 2021 May 7;22(9):4953. doi: 10.3390/ijms22094953.
3
Night shift schedule alters endogenous regulation of circulating cytokines.夜班排班改变循环细胞因子的内源性调节。
Neurobiol Sleep Circadian Rhythms. 2021 Mar 5;10:100063. doi: 10.1016/j.nbscr.2021.100063. eCollection 2021 May.
4
Prevalence and correlates of traditional risk factors for cardiovascular disease in a Nigerian ART-naive HIV population: a cross-sectional study.尼日利亚未接受抗逆转录病毒治疗的HIV人群中心血管疾病传统危险因素的患病率及其相关因素：一项横断面研究。
BMJ Open. 2018 Jul 19;8(7):e019664. doi: 10.1136/bmjopen-2017-019664.
5
An insight of sleep disorders in Africa.对非洲睡眠障碍的洞察。
eNeurologicalSci. 2016 Feb 26;3:37-40. doi: 10.1016/j.ensci.2016.02.006. eCollection 2016 Jun.
6
Decreased limb muscle and increased central adiposity are associated with 5-year all-cause mortality in HIV infection.肢体肌肉减少和中心性肥胖与 HIV 感染患者 5 年全因死亡率相关。
AIDS. 2011 Jul 17;25(11):1405-14. doi: 10.1097/QAD.0b013e32834884e6.
7
Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy.加速性肌肉减少症模型：解决与年龄相关的肌肉萎缩之谜的关键。
Ageing Res Rev. 2010 Oct;9(4):369-83. doi: 10.1016/j.arr.2010.04.004. Epub 2010 May 14.
8
Interleukin-1 stimulates catabolism in C2C12 myotubes.白细胞介素-1刺激C2C12肌管中的分解代谢。
Am J Physiol Cell Physiol. 2009 Sep;297(3):C706-14. doi: 10.1152/ajpcell.00626.2008. Epub 2009 Jul 22.
9
C-reactive protein independently predicts HIV-related outcomes among women and children in a resource-poor setting.在资源匮乏地区，C反应蛋白可独立预测妇女和儿童的HIV相关结局。
AIDS. 2007 Oct 1;21(15):2067-75. doi: 10.1097/QAD.0b013e32826fb6c7.
10
A comparison of the binding sites of matrix metalloproteinases and tumor necrosis factor-alpha converting enzyme: implications for selectivity.基质金属蛋白酶与肿瘤坏死因子-α转化酶结合位点的比较：对选择性的影响
J Med Chem. 2005 Apr 7;48(7):2361-70. doi: 10.1021/jm0491703.

本文引用的文献

1
Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-alpha in rodents.啮齿动物对高剂量重组肿瘤坏死因子-α胃肠道效应产生部分耐受性的发展。
J Clin Invest. 1987 Dec;80(6):1587-96. doi: 10.1172/JCI113245.
2
Idiopathic production of interleukin-1 in acquired immune deficiency syndrome.获得性免疫缺陷综合征中白细胞介素-1的特发性产生。
J Clin Microbiol. 1987 Sep;25(9):1695-700. doi: 10.1128/jcm.25.9.1695-1700.1987.
3
Interleukin 1 inhibitor masks high interleukin 1 production in acquired immunodeficiency syndrome (AIDS).
Clin Immunol Immunopathol. 1987 Jan;42(1):133-40. doi: 10.1016/0090-1229(87)90180-2.
4
Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome.获得性免疫缺陷综合征患者循环中恶病质素/肿瘤坏死因子水平升高。
Am J Med. 1988 Sep;85(3):289-91. doi: 10.1016/0002-9343(88)90576-1.
5
The role of tumor necrosis factor (cachectin) in cachexia.肿瘤坏死因子（恶病质素）在恶病质中的作用。
Cell. 1988 Jul 15;54(2):141-2. doi: 10.1016/0092-8674(88)90543-0.
6
Neopterin and alpha and beta interleukin-1 levels in sera of patients with human immunodeficiency virus infection.人类免疫缺陷病毒感染患者血清中的新蝶呤以及α和β白细胞介素-1水平。
J Clin Microbiol. 1989 Sep;27(9):1919-23. doi: 10.1128/jcm.27.9.1919-1923.1989.
7
Interleukin-1-induced anorexia in the rat. Influence of prostaglandins.白细胞介素-1诱导大鼠厌食。前列腺素的影响。
J Clin Invest. 1989 Jul;84(1):228-35. doi: 10.1172/JCI114145.
8
Infection with HIV is associated with elevated IL-6 levels and production.感染HIV与白细胞介素-6水平升高及产生有关。
J Immunol. 1990 Jan 15;144(2):480-4.
9
Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF.人血单核细胞中白细胞介素-6（IL-6）、白细胞介素-1（IL-1）和肿瘤坏死因子（TNF）产生过程中的相关性及相互作用：IL-6抑制IL-1和TNF。
Blood. 1990 Jan 1;75(1):40-7.
10
Metabolic effects of cachectin/tumor necrosis factor are modified by site of production. Cachectin/tumor necrosis factor-secreting tumor in skeletal muscle induces chronic cachexia, while implantation in brain induces predominantly acute anorexia.恶病质素/肿瘤坏死因子的代谢效应因产生部位而异。骨骼肌中分泌恶病质素/肿瘤坏死因子的肿瘤会诱发慢性恶病质，而将其植入脑内则主要诱发急性厌食。
J Clin Invest. 1990 Dec;86(6):2014-24. doi: 10.1172/JCI114937.