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自身抗体的诊断特异性。III. 自身抗体血清IgD水平出现的年龄相关变化及其与外周血淋巴细胞谱的关联。

Diagnostic specificity of autoantibodies. III. Age related changes in appearing autoantibodies serum IgD levels and their association with peripheral blood lymphocyte profiles.

作者信息

Lange A, Garncarek D, Charzyńska E, Mydlak H

出版信息

Arch Immunol Ther Exp (Warsz). 1978;26(1-6):887-91.

PMID:749837
Abstract

Comparisons made between old and young people depicted the increase with aging in ANA and thyroid antibody incidence. In contrast to these antibodies SMA were frequently seen in young women. Also in women serum IgM levels were higher as compared to men. Conversely serum IgD levels were higher in men; both these differences were seen in the young group only. Proportions and numbers of E-RFC were significantly reduced in the older group of people as compared to the values of the younger group. Interestingly, the autoantibodies appearing were correlated in women with a lower percentage of E-RFC. Also in women low IgD levels were associated significantly with higher percentage of E-RFC.

摘要

对老年人和年轻人进行的比较显示,抗核抗体(ANA)和甲状腺抗体的发生率随年龄增长而增加。与这些抗体不同,平滑肌抗体(SMA)在年轻女性中更为常见。此外,女性的血清IgM水平高于男性。相反,男性的血清IgD水平较高;这两种差异仅在年轻组中出现。与年轻组相比,老年组的E-玫瑰花结形成细胞(E-RFC)比例和数量显著降低。有趣的是,出现的自身抗体在女性中与较低比例的E-RFC相关。同样,在女性中,低IgD水平也与较高比例的E-RFC显著相关。

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