Tanaka H, Hiyama T, Okubo Y, Kitada A, Fujimoto I
Department of Field Research, Center for Adult Diseases, Osaka, Japan.
Cancer Causes Control. 1994 Jan;5(1):61-5. doi: 10.1007/BF01830727.
Osaka, Japan, has one of the highest, primary liver cancer (PLC) incidence-rates in the world, although hepatitis-B virus (HBV) is not endemic. This paper addresses the question of whether the PLC-incidence variation within Osaka Prefecture is due to differences in the prevalence of hepatitis-C virus (HCV) infection. The screening data of antibody to HCV (anti-HCV) and of hepatitis-B virus antigen (HBsAg) in 111,069 male blood-donors, and the incidence data of male PLC obtained from the Osaka Cancer Registry were examined. In a multiple-weighted regression analysis, the age-standardized incidence rate of PLC in the 61 counties within Osaka was correlated significantly with the age-standardized prevalence of anti-HCV with adjustment for that of HBsAg (regression coefficient [RC] = 7.26, P < 0.0001). This finding was consistent with the relationship between the PLC incidence rate and the prevalence of high-titer (> or = 2(12)) anti-HCV (RC = 11.18, P < 0.0001). There was significant association between the prevalence of HBsAg and the PLC incidence rate with adjustment for that of anti-HCV (RC = 7.08, P = 0.018). These findings suggest that the PLC-incidence variation within Osaka is correlated with the geographic pattern of HCV infection as well as that of HBV infection among the residents.
日本大阪是世界上原发性肝癌（PLC）发病率最高的地区之一，尽管乙肝病毒（HBV）并非地方流行性病原体。本文探讨了大阪府内PLC发病率的差异是否归因于丙型肝炎病毒（HCV）感染率的不同。研究人员检查了111,069名男性献血者的HCV抗体（抗-HCV）和乙肝病毒抗原（HBsAg）的筛查数据，以及从大阪癌症登记处获得的男性PLC发病率数据。在多元加权回归分析中，大阪61个县内PLC的年龄标准化发病率与抗-HCV的年龄标准化患病率显著相关，并对HBsAg的患病率进行了校正（回归系数[RC]=7.26，P<0.0001）。这一发现与PLC发病率和高滴度（≥2(12)）抗-HCV患病率之间的关系一致（RC=11.18，P<0.0001）。在对抗-HCV患病率进行校正后，HBsAg患病率与PLC发病率之间存在显著关联（RC=7.08，P=0.018）。这些发现表明，大阪府内PLC发病率的差异与居民中HCV感染的地理分布模式以及HBV感染的地理分布模式相关。
