血友病患者中乙型肝炎和丙型肝炎感染的相互作用

Interaction of hepatitis B and hepatitis C infection in haemophilia.

作者信息

Hanley J P, Dolan G, Day S, Skidmore S J, Irving W L

机构信息

Department of Haematology, University Hospital, Nottingham.

出版信息

Br J Haematol. 1993 Nov;85(3):611-2. doi: 10.1111/j.1365-2141.1993.tb03356.x.

DOI:10.1111/j.1365-2141.1993.tb03356.x

PMID:7510994

Abstract

The management of haemophilia has been greatly complicated by the clinical sequelae of viral infection acquired through contaminated blood products. Many haemophiliacs have been infected by several viruses and the interaction between these viruses may be complex. In a cohort of 42 anti-HCV positive haemophiliacs, five were also found to be positive for HBsAg. All five were HCV reverse transcriptase/PCR negative compared to the 4/37 (11%) anti-HCV positive haemophiliacs who were HBsAg negative (P = 0.0001). We have identified a striking interaction between hepatitis C (HCV) and hepatitis B (HBV) in haemophiliacs co-infected by these agents, suggestive of the phenomenon of viral interference.

摘要

通过受污染血液制品感染病毒所引发的临床后遗症，极大地增加了血友病治疗的复杂性。许多血友病患者感染了多种病毒，这些病毒之间的相互作用可能很复杂。在一组42名抗丙型肝炎病毒（HCV）呈阳性的血友病患者中，还发现有5名乙肝表面抗原（HBsAg）呈阳性。与4/37（11%）抗HCV呈阳性且HBsAg呈阴性的血友病患者相比，这5名患者的HCV逆转录酶/聚合酶链反应（PCR）均为阴性（P = 0.0001）。我们发现，同时感染丙型肝炎病毒（HCV）和乙型肝炎病毒（HBV）的血友病患者中，这两种病毒之间存在显著的相互作用，提示存在病毒干扰现象。