Ruilope L M, Campo C, Lahera V
Unidad de Hipertensión, Hospital 12 de Octubre, Madrid, Spain.
Drugs. 1993;46 Suppl 2:108-12. doi: 10.2165/00003495-199300462-00019.
It has been known for some time that a relationship exists between the kidney and blood pressure. The renal origin of arterial hypertension has been demonstrated in different animal models resembling human hypertension, with data from humans seeming to confirm this hypothesis. On the other hand, the renal vasculature also suffers the consequences of arterial hypertension, and renal insufficiency can develop as a result of elevated blood pressure levels. Antihypertensive therapy can prevent the development of renal damage secondary to hypertension. For example, calcium antagonists possess specific renal effects that not only facilitate their antihypertensive capacity but also protect the kidney from the development of renal failure.
一段时间以来，人们已经知道肾脏与血压之间存在关联。在不同的类似于人类高血压的动物模型中，已经证实了动脉高血压的肾脏起源，来自人类的数据似乎也证实了这一假设。另一方面，肾血管系统也会受到动脉高血压的影响，血压升高可能会导致肾功能不全。抗高血压治疗可以预防高血压继发的肾损伤。例如，钙拮抗剂具有特定的肾脏效应，不仅有助于其抗高血压能力，还能保护肾脏免受肾衰竭的发展。
