Kadekaro M, Terrell M L, Harmann P, Summy-Long J Y
Division of Neurosurgery, University of Texas Medical Branch at Galveston 77555-0517.
Neurosci Lett. 1994 May 23;173(1-2):115-8. doi: 10.1016/0304-3940(94)90162-7.
I.c.v. administration of a nitric oxide (NO) synthase inhibitor (NG-monomethyl-L-arginine, NMMA, 500 micrograms/5 microliters) to conscious rats deprived of water for 24 h attenuated drinking and decreased glucose utilization in the subfornical organ and median preoptic nucleus. NMMA did not alter the enhanced glucose utilization in the hypothalamo-neurohypophysial system (HNS) of dehydrated rats, although it has been shown to increase, selectively, oxytocin (OT) secretion [18]. This suggests that NO may act in the neural lobe to inhibit OT secretion and promote the preferential release of vasopressin during dehydration. This effect is similar to the blockade of endogenous opiate receptors by naloxone.
向禁水24小时的清醒大鼠脑室内注射一氧化氮（NO）合酶抑制剂（Nω-甲基-L-精氨酸，NMMA，500微克/5微升），可减弱饮水，并降低穹窿下器和视前正中核的葡萄糖利用率。尽管已表明NMMA可选择性增加催产素（OT）分泌[18]，但它并未改变脱水大鼠下丘脑-神经垂体系统（HNS）中增强的葡萄糖利用率。这表明，NO可能在神经叶中发挥作用，抑制OT分泌，并在脱水过程中促进血管加压素的优先释放。这种作用类似于纳洛酮对内源性阿片受体的阻断作用。
