Bertheim U, Hellström S
Department of Plastic Surgery, University of Umeå, Sweden.
Br J Plast Surg. 1994 Oct;47(7):483-9. doi: 10.1016/0007-1226(94)90031-0.
A hyaluronan-binding protein (HABP) was used to locate the distribution of HA in normal skin and in various types of scar tissue: mature scar tissue, hypertrophic scar tissue and keloids. The study was intended to establish whether or not a deviant HA distribution could explain the different clinical features of these scar tissues. The distribution of HA was found to differ between the various scar tissues. In normal skin an intense HA-staining was observed in the papillary dermis. In mature scar tissue the distribution of HA resembled that of normal uninjured tissue, but the layer of HA was thinner. In hypertrophic scar tissue, HA occurred mainly as a narrow strip in the papillary dermis. Keloid tissue showed the least HA-staining of the papillary layer and resembled that of the bulging reticular dermis. In contrast, the thickened granular and spinous layer of the keloid epidermis exhibited an intense HA-staining. We suggest that the altered distribution and amount of HA in these different scar tissues may contribute to their different clinical characteristics. This histochemical technique for the demonstration of HA in scar tissue could be of use in clinical work to decide on therapeutic strategies.
一种透明质酸结合蛋白（HABP）被用于定位透明质酸（HA）在正常皮肤以及各类瘢痕组织中的分布：成熟瘢痕组织、增生性瘢痕组织和瘢痕疙瘩。该研究旨在确定HA分布异常是否能够解释这些瘢痕组织不同的临床特征。研究发现，不同瘢痕组织中HA的分布存在差异。在正常皮肤中，乳头层真皮呈现强烈的HA染色。在成熟瘢痕组织中，HA的分布与正常未损伤组织相似，但HA层较薄。在增生性瘢痕组织中，HA主要呈现为乳头层真皮中的一条窄带。瘢痕疙瘩组织的乳头层HA染色最少，与隆起的网状真皮相似。相反，瘢痕疙瘩表皮增厚的颗粒层和棘层呈现强烈的HA染色。我们认为，这些不同瘢痕组织中HA分布和含量的改变可能导致了它们不同的临床特征。这种用于在瘢痕组织中显示HA的组织化学技术在临床工作中有助于制定治疗策略。
