Froehlich J, Kaufman D I
Michigan State University, Department of Internal Medicine, East Lansing 48824.
Electroencephalogr Clin Neurophysiol. 1994 Nov;92(6):480-6. doi: 10.1016/0168-5597(94)90131-7.
The transient pattern electroretinogram (PERG) was recorded from 16 patients with acute optic neuritis and from 13 patients with acute non-arteritic anterior ischemic optic neuropathy (AION). All patients were tested within 35 days from the the onset of visual symptoms and all had significant central visual field abnormalities in their affected eyes as quantified by automated perimetry. Analysis of the PERGs showed that the amplitude of the N95 peak was abnormally reduced for each eye affected with AION while it remained normal in optic neuritis. No significant alteration in P50 amplitude was observed in either condition. The loss of N95 amplitude in AION was highly correlated with the average depth of visual field loss (in decibels) within a radius of 10 degrees of fixation. These results suggest that PERG could be used early in the course of optic neuropathy to distinguish optic neuritis from AION in those cases for which the diagnosis is still uncertain after the clinical examination.
对16例急性视神经炎患者和13例急性非动脉炎性前部缺血性视神经病变（AION）患者进行了瞬态图形视网膜电图（PERG）记录。所有患者均在出现视觉症状后的35天内接受检测，并且通过自动视野计测量发现，所有患者患眼均有明显的中心视野异常。PERG分析显示，AION患眼的N95波峰振幅异常降低，而视神经炎患者的该振幅保持正常。在两种情况下均未观察到P50振幅有明显改变。AION患者N95振幅的降低与在注视点10度范围内视野缺损的平均深度（以分贝为单位）高度相关。这些结果表明，在视神经病变过程的早期，对于那些临床检查后诊断仍不确定的病例，PERG可用于区分视神经炎和AION。
