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委内瑞拉马脑炎病毒保护性相关的四个抗原位点的定位

Localization of four antigenic sites involved in Venezuelan equine encephalomyelitis virus protection.

作者信息

Agapov E V, Razumov I A, Frolov I V, Kolykhalov A A, Netesov S V, Loktev V B

机构信息

Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Russia.

出版信息

Arch Virol. 1994;139(1-2):173-81. doi: 10.1007/BF01309462.

DOI:10.1007/BF01309462
PMID:7529989
Abstract

Stable neutralization and protection escape variants of a virulent strain (Trinidad Donkey) of the VEE virus were selected by monoclonal antibodies (MAbs). Determination of nucleotide sequences of nine variants revealed a clustering of single mutations in four regions of the E1 and E2 glycoproteins. Involvement of amino acid residues 206 (site E1-1), 57 and 59 (site E2-2), 180, 182, 213, 214 and 216 (site E2-6) and 232 (site E2-3) in protective epitopes was demonstrated.

摘要

通过单克隆抗体（MAb）筛选出委内瑞拉马脑炎病毒（VEE病毒）强毒株（特立尼达驴毒株）的稳定中和及保护性逃逸变异株。对九个变异株的核苷酸序列测定显示，E1和E2糖蛋白四个区域存在单突变聚集现象。证实了206位氨基酸残基（E1-1位点）、57和59位氨基酸残基（E2-2位点）、180、182、213、214和216位氨基酸残基（E2-6位点）以及232位氨基酸残基（E2-3位点）参与保护性表位。

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Localization of four antigenic sites involved in Venezuelan equine encephalomyelitis virus protection.委内瑞拉马脑炎病毒保护性相关的四个抗原位点的定位
Arch Virol. 1994;139(1-2):173-81. doi: 10.1007/BF01309462.
2
Glycoproteins E2 of the Venezuelan and eastern equine encephalomyelitis viruses contain multiple cross-reactive epitopes.委内瑞拉马脑炎病毒和东部马脑炎病毒的糖蛋白E2含有多个交叉反应表位。
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Variants of Venezuelan equine encephalitis virus that resist neutralization define a domain of the E2 glycoprotein.抗中和的委内瑞拉马脑炎病毒变种定义了E2糖蛋白的一个结构域。
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Attenuation of Venezuelan equine encephalitis virus strain TC-83 is encoded by the 5'-noncoding region and the E2 envelope glycoprotein.委内瑞拉马脑炎病毒株TC-83的减毒由5'-非编码区和E2包膜糖蛋白编码。
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[Epitope specificity and protective activity of monoclonal antibodies to Venezuelan equine encephalomyelitis virus].[针对委内瑞拉马脑炎病毒的单克隆抗体的表位特异性及保护活性]
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[The antigenic structure of glycoprotein E2 in the Venezuelan equine encephalomyelitis virus studied using rat monoclonal antibodies].[利用大鼠单克隆抗体研究委内瑞拉马脑炎病毒中糖蛋白E2的抗原结构]
Vopr Virusol. 1991 Jan-Feb;36(1):34-7.

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Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses.节肢动物传播病毒的血凝及血凝抑制技术。
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[The peptide mapping of the E2-2 and E2-6 sites of the E2 glycoprotein in the Venezuelan equine encephalomyelitis virus].[委内瑞拉马脑炎病毒E2糖蛋白E2-2和E2-6位点的肽图谱分析]
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Structure and assembly of alphaviruses.甲病毒的结构与组装
Pathogens. 2021 Jul 31;10(8):973. doi: 10.3390/pathogens10080973.
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Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein.针对东部马脑炎病毒的保护性抗体与 E2 糖蛋白的 A 域和 B 域中的表位结合。
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