Eriksson M, Zetterström R
Department of Pediatrics, St Göran's Children's Hospital, Stockholm, Sweden.
Acta Paediatr Suppl. 1994 Nov;404:27-31. doi: 10.1111/j.1651-2227.1994.tb13380.x.
Sixty-five children born to women who all used amphetamine during pregnancy have been followed prospectively since birth 1976-77. They have been tested and examined at one, 4 and 8 years of age. In addition, information about the school situation was collected after 10 years. Twenty percent of the children were put in foster homes at birth, and after 10 years 70% were in foster homes. The children showed a normal intellectual capacity. However, at 10 years of age 8 children (12%) attended one class below what was normal for their biological age (normal in Sweden < 5%). At 4 years of age 35% had an aggressive behaviour and at 8 years 23%. There was a statistically significant correlation between aggressive behaviour and amphetamine exposure during fetal life. At both 4 and 8 years of age 40% were considered to have a poor adjustment, which correlated with socio-environmental factors. Lower values for weight and length also showed a correlation with socio-environmental factors. The study shows that amphetamine abuse during pregnancy will influence development of exposed children at least up to the age of 10 years.
自1976 - 1977年出生以来，对65名母亲在孕期均使用过苯丙胺的儿童进行了前瞻性跟踪研究。这些儿童在1岁、4岁和8岁时接受了测试和检查。此外，10年后收集了有关他们在校情况的信息。20%的儿童出生后被送入寄养家庭，10年后这一比例为70%。这些儿童的智力水平正常。然而，10岁时，有8名儿童（12%）所在班级比按其实际年龄应处的正常班级低一级（在瑞典，正常比例<5%）。4岁时，35%的儿童有攻击性行为，8岁时这一比例为23%。胎儿期接触苯丙胺与攻击性行为之间存在统计学上的显著相关性。在4岁和8岁时，均有40%的儿童被认为适应不良，这与社会环境因素相关。体重和身高较低也与社会环境因素相关。该研究表明，孕期滥用苯丙胺至少会对受影响儿童10岁前的发育产生影响。
