Kumon Y, Suehiro T, Itahara T, Ikeda Y, Hashimoto K
Second Department of Internal Medicine, Kochi Medical School, Japan.
Clin Biochem. 1994 Dec;27(6):469-73. doi: 10.1016/0009-9120(94)00044-v.
We determined the serum amyloid A protein (SAA) levels in patients with non-insulin-dependent diabetes mellitus (NIDDM), and investigated the possible association between SAA and the complications of NIDDM. The concentrations of SAA were measured in the plasma of 105 patients with NIDDM (52 men and 53 women, age mean +/- SD, 61 +/- 13 years) and 91 healthy subjects (37 men and 54 women, aged 57 +/- 11 years). SAA concentrations were assayed by enzyme-linked immunosorbent assay. SAA concentrations in the patients with NIDDM were significantly higher than those in healthy subjects (2.1 +/- 1.3 vs. 1.2 +/- 0.5 mg/L). There were no obvious relationships between SAA levels and duration of diabetes, type of therapy, or control of blood sugar in the patients with NIDDM. However, SAA levels in patients with NIDDM increased significantly, with increase of urinary albumin excretion (p = 0.027). The increase of SAA in the patients with NIDDM did not influence the serum concentrations of lipid or lipoprotein. The SAA concentration in NIDDM was unrelated to the type of treatment, but seemed to be related to the development of diabetic nephropathy.
我们测定了非胰岛素依赖型糖尿病（NIDDM）患者的血清淀粉样蛋白A（SAA）水平，并研究了SAA与NIDDM并发症之间可能存在的关联。检测了105例NIDDM患者（52例男性和53例女性，年龄均值±标准差为61±13岁）和91例健康受试者（37例男性和54例女性，年龄为57±11岁）血浆中的SAA浓度。采用酶联免疫吸附测定法检测SAA浓度。NIDDM患者的SAA浓度显著高于健康受试者（2.1±1.3 vs. 1.2±0.5mg/L）。NIDDM患者的SAA水平与糖尿病病程、治疗类型或血糖控制之间无明显关系。然而，NIDDM患者的SAA水平随尿白蛋白排泄量的增加而显著升高（p = 0.027）。NIDDM患者SAA的升高并未影响血脂或脂蛋白的血清浓度。NIDDM患者的SAA浓度与治疗类型无关，但似乎与糖尿病肾病的发生有关。
