Iishi H, Tatsuta M, Baba M, Uehara H, Yano H, Nakaizumi A
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
Int J Cancer. 1995 Jun 9;61(6):861-3. doi: 10.1002/ijc.2910610619.
The effects of the neuropeptide galanin on the development of colon tumors induced by azoxymethane (AOM) and on the labeling index of colon epithelial cells were investigated in Wistar rats. Treatment with galanin significantly decreased the incidence of colon tumors at week 45. Galanin did not influence the histological appearance of the colon tumors, but it slightly increased the frequency of sub-mucosal adenocarcinomas. Furthermore, it significantly decreased the labeling index of colon mucosa during and after AOM treatment. These findings indicate that galanin inhibited the development of colon tumors and that this effect may be related to its suppression of colon-epithelial-cell proliferation.
在Wistar大鼠中研究了神经肽甘丙肽对由氧化偶氮甲烷（AOM）诱导的结肠肿瘤发生及结肠上皮细胞标记指数的影响。甘丙肽治疗显著降低了45周时结肠肿瘤的发生率。甘丙肽不影响结肠肿瘤的组织学外观，但略微增加了粘膜下腺癌的发生率。此外，它显著降低了AOM治疗期间及之后结肠粘膜的标记指数。这些发现表明甘丙肽抑制结肠肿瘤的发生，且这种作用可能与其对结肠上皮细胞增殖的抑制有关。
