INSERM, UMRS_968, Institut de la Vision, Department of Development, 17 rue Moreau, Paris, France.
Cold Spring Harb Perspect Biol. 2010 Jun;2(6):a001917. doi: 10.1101/cshperspect.a001917. Epub 2010 May 12.
The mammalian brain is the most complex organ in the body. It controls all aspects of our bodily functions and interprets the world around us through our senses. It defines us as human beings through our memories and our ability to plan for the future. Crucial to all these functions is how the brain is wired in order to perform these tasks. The basic map of brain wiring occurs during embryonic and postnatal development through a series of precisely orchestrated developmental events regulated by specific molecular mechanisms. Below we review the most important features of mammalian brain wiring derived from work in both mammals and in nonmammalian species. These mechanisms are highly conserved throughout evolution, simply becoming more complex in the mammalian brain. This fascinating area of biology is uncovering the essence of what makes the mammalian brain able to perform the everyday tasks we take for granted, as well as those which give us the ability for extraordinary achievement.
哺乳动物的大脑是人体中最复杂的器官。它控制着我们身体功能的各个方面，并通过我们的感官来感知周围的世界。我们的记忆和对未来的规划能力使我们成为人类。所有这些功能的关键在于大脑的布线方式，以便执行这些任务。大脑布线的基本图谱是在胚胎期和出生后通过一系列精确协调的发育事件发生的，这些事件受特定分子机制的调节。下面，我们将回顾从哺乳动物和非哺乳动物物种的工作中得出的关于哺乳动物大脑布线的最重要特征。这些机制在进化过程中高度保守，只是在哺乳动物大脑中变得更加复杂。这一引人入胜的生物学领域正在揭示是什么使哺乳动物的大脑能够完成我们认为理所当然的日常任务，以及赋予我们非凡成就的能力。
